Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.68 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.68 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.68 |
| ▸ | CDK2 | P24941 | 5/20 | 0.67 |
| ▸ | NEK2 | P51955 | 2/20 | 0.66 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.66 |
| ▸ | SRC | P12931 | 2/20 | 0.66 |
| ▸ | CDK1 | P06493 | 2/20 | 0.66 |
| ▸ | AURKA | O14965 | 1/20 | 0.66 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.66 |
| ▸ | ABL1 | P00519 | 1/20 | 0.66 |
| ▸ | LCK | P06239 | 1/20 | 0.66 |
| ▸ | FYN | P06241 | 1/20 | 0.66 |
| ▸ | LYN | P07948 | 1/20 | 0.66 |
| ▸ | MET | P08581 | 1/20 | 0.66 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.66 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.66 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.66 |
| ▸ | AKT2 | P31751 | 1/20 | 0.66 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7112087 | 0.92 | CDK2 (0.62) | ADORA3ADORA2AADORA1CDK2NEK2 | |
| SCHEMBL7110005 | 0.85 | BRAF (0.60) | ADORA3ADORA2AADORA1CDK2BRAF | |
| SCHEMBL16146541 | 0.83 | TNNI3K (0.62) | ADORA3ADORA2AADORA1CDK2SRC | |
| SCHEMBL3007353 | 0.83 | SRC (0.56) | ADORA3ADORA2AADORA1CDK2NEK2 | |
| SCHEMBL8539783 | 0.83 | CDK2 (0.64) | ADORA3ADORA2AADORA1CDK2NEK2 | |
| SCHEMBL16147002 | 0.83 | CDK2 (0.64) | ADORA3ADORA2AADORA1CDK2NEK2 | |
| SCHEMBL16146744 | 0.83 | BRAF (0.58) | ADORA3ADORA2AADORA1CDK2NEK2 | |
| SCHEMBL11015321 | 0.83 | SRC (0.56) | ADORA3ADORA2AADORA1CDK2SRC | |
| SCHEMBL5355413 | 0.83 | BRAF (0.73) | CDK1BRAF | |
| SCHEMBL3001381 | 0.83 | TNNI3K (0.61) | SRCBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200435-B1 | PURINE DERIVATIVES INHIBITORS OF TYROSINE PROTEIN KINASE SYK | NOVARTIS AG (CH) | 2003-10-01 | — | — | EP | claimed |
| US-6589950-B1 | Treatment of inflammatory or obstructive airways disease for respiratory system disorders | NOVARTIS AG (CH) | 2003-07-08 | — | — | US | claimed |
| JP-2003506375-A | — | — | 2003-02-18 | — | — | JP | claimed |
| EP-1200435-A1 | PURINE DERIVATIVES INHIBITORS OF TYROSINE PROTEIN KINASE SYK | Novartis AG (CH) | 2002-05-02 | — | — | EP | claimed |
| WO-2001009134-A1 | PURINE DERIVATIVES INHIBITORS OF TYROSINE PROTEIN KINASE SYK | NOVARTIS AG (CH) | 2001-02-08 | — | — | WO | claimed |
| EP-3149207-A2 | ACTIVATING JAK KINASE BIOMARKERS PREDICTIVE OF ANTI-IMMUNE CHECKPOINT INHIBITOR RESPONSE | Dana-Farber Cancer Institute, Inc. (US) | 2017-04-05 | — | — | EP | disclosed |
| EP-3004388-A2 | DETECTION AND QUANTIFICATION OF DONOR CELL-FREE DNA IN THE CIRCULATION OF ORGAN TRANSPLANT RECIPIENTS | Chronix Biomedical (US) | 2016-04-13 | — | — | EP | disclosed |
| WO-2015184061-A2 | ACTIVATING JAK KINASE BIOMARKERS PREDICTIVE OF ANTI-IMMUNE CHECKPOINT INHIBITOR RESPONSE | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2015-12-03 | — | — | WO | disclosed |
| WO-2014194113-A2 | DETECTION AND QUANTIFICATION OF DONOR CELL-FREE DNA IN THE CIRCULATION OF ORGAN TRANSPLANT RECIPIENTS | CHRONIX BIOMEDICAL (US) | 2014-12-04 | — | — | WO | disclosed |
| WO-2012012710-A2 | RADIATION SENSITIZATION AGENTS FOR PROSTATE CANCER | THE JOHNS HOPKINS UNIVERSITY (US) | 2012-01-26 | — | — | WO | disclosed |
| WO-2011011710-A1 | METHODS OF TREATING VIRAL INFECTIONS | CHIMERIX, INC. (US) | 2011-01-27 | — | — | WO | disclosed |
| EP-1390497-A2 | HUMAN CDNAS AND PROTEINS AND USES THEREOF | Genset (FR) | 2004-02-25 | — | — | EP | disclosed |
| EP-1200435-B1 | PURINE DERIVATIVES INHIBITORS OF TYROSINE PROTEIN KINASE SYK | NOVARTIS AG (CH) | 2003-10-01 | — | — | EP | disclosed |
| US-6589950-B1 | Treatment of inflammatory or obstructive airways disease for respiratory system disorders | NOVARTIS AG (CH) | 2003-07-08 | — | — | US | disclosed |
| WO-2002094864-A2 | HUMAN CDNAS AND PROTEINS AND USES THEREOF | GENSET S.A. (FR) | 2002-11-28 | — | — | WO | disclosed |
| EP-1200435-A1 | PURINE DERIVATIVES INHIBITORS OF TYROSINE PROTEIN KINASE SYK | Novartis AG (CH) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001009134-A1 | PURINE DERIVATIVES INHIBITORS OF TYROSINE PROTEIN KINASE SYK | NOVARTIS AG (CH) | 2001-02-08 | — | — | WO | disclosed |