Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 6/20 | 0.66 |
| ▸ | KDR | P35968 | 4/20 | 0.65 |
| ▸ | EGFR | P00533 | 10/20 | 0.65 |
| ▸ | AURKA | O14965 | 5/20 | 0.63 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.63 |
| ▸ | LCK | P06239 | 2/20 | 0.63 |
| ▸ | RET | P07949 | 2/20 | 0.63 |
| ▸ | MET | P08581 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | LTK | P29376 | 2/20 | 0.63 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.63 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.63 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | FYN | P06241 | 1/20 | 0.63 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.63 |
| ▸ | TTK | P33981 | 1/20 | 0.63 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.63 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.63 |
| ▸ | BTK | Q06187 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2998290 | 0.90 | EGFR (0.70) | SRCKDREGFRERBB2 | |
| SCHEMBL2991319 | 0.90 | EGFR (0.71) | SRCKDREGFRLCKRET | |
| SCHEMBL5369287 | 0.90 | SRC (0.65) | SRCKDREGFRLCKRET | |
| SCHEMBL13529060 | 0.88 | SRC (0.84) | SRCKDREGFRAURKAAURKB | |
| SCHEMBL29087945 | 0.85 | KDR (0.60) | SRCKDREGFRAURKAAURKB | |
| SCHEMBL12694411 | 0.85 | EGFR (0.66) | SRCKDREGFRAURKAAURKB | |
| SCHEMBL2963866 | 0.85 | EGFR (0.80) | SRCKDREGFRAURKBLCK | |
| SCHEMBL4586680 | 0.84 | EGFR (0.61) | SRCKDREGFRAURKAAURKB | |
| SCHEMBL23406671 | 0.84 | EGFR (0.68) | SRCKDREGFRAURKBLCK | |
| SCHEMBL29944978 | 0.84 | EGFR (0.68) | SRCKDREGFRAURKBLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1594504-A4 | NOVEL IRREVERSIBLE INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR TYROSINE KINASE AND USES THEREOF FOR THERAPY AND DIAGNOSIS | T K SIGNAL LTD (IL) | 2008-12-17 | — | — | EP | disclosed |
| US-20060025430-A1 | Novel irreversible inhibitors of epidermal growth factor receptor tyrosine kinase and uses thereof for therapy and diagnosis | T.K. SIGNAL LTD. (IL) | 2006-02-02 | — | — | US | disclosed |
| EP-1594504-A2 | NOVEL IRREVERSIBLE INHIBITORS OF EPIDERMAL GROWTH FACTOR RECEPTOR TYROSINE KINASE AND USES THEREOF FOR THERAPY AND DIAGNOSIS | T.K. Signal Ltd. (IL) | 2005-11-16 | — | — | EP | disclosed |
| WO-2004064718-A2 | IRREVERSIBLE INHIBITORS OF EGF RECEPTOR TYROSINE KINASES AND USES THEREOF | T.K. SIGNAL LTD. (IL) | 2004-08-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060025430-A1 | Novel irreversible inhibitors of epidermal growth factor receptor tyrosine kinase and uses thereof for therapy and diagnosis | EGFR, ERBB2, ERBB3 | SRC 28/4885KDR 18/4885EGFR 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.