Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 7/20 | 0.84 |
| ▸ | KDR | P35968 | 7/20 | 0.83 |
| ▸ | EGFR | P00533 | 9/20 | 0.80 |
| ▸ | AURKA | O14965 | 5/20 | 0.80 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.80 |
| ▸ | LCK | P06239 | 2/20 | 0.80 |
| ▸ | RET | P07949 | 2/20 | 0.80 |
| ▸ | MET | P08581 | 2/20 | 0.80 |
| ▸ | MAPT | P10636 | 2/20 | 0.80 |
| ▸ | LTK | P29376 | 2/20 | 0.80 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.80 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.80 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.80 |
| ▸ | FYN | P06241 | 1/20 | 0.80 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.80 |
| ▸ | TTK | P33981 | 1/20 | 0.80 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.80 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.80 |
| ▸ | BTK | Q06187 | 1/20 | 0.80 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3531151 | 0.92 | SRC (0.86) | SRCKDREGFRAURKAAURKB | |
| SCHEMBL28424819 | 0.91 | SRC (0.85) | SRCKDREGFRAURKAAURKB | |
| SCHEMBL28350517 | 0.90 | SRC (0.77) | SRCKDREGFRAURKAAURKB | |
| SCHEMBL6906285 | 0.90 | KDR (0.82) | SRCKDREGFRLCKRET | |
| SCHEMBL28354308 | 0.90 | SRC (0.77) | SRCKDREGFRAURKAAURKB | |
| Hydrochloric Acid SCHEMBL30891785 | 0.90 | EGFR (0.84) | SRCKDREGFRAURKAAURKB | |
| SCHEMBL1155807 | 0.89 | SRC (0.81) | SRCKDREGFRAURKAAURKB | |
| SCHEMBL29377224 | 0.89 | EGFR (1.00) | SRCKDREGFRAURKAAURKB | |
| SCHEMBL597105 | 0.89 | EGFR (1.00) | SRCKDREGFRAURKAAURKB | |
| Hydrochloric Acid SCHEMBL3535974 | 0.89 | EGFR (0.80) | SRCKDREGFRAURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100022467-A1 | ANTI-CANCER PHOSPHONATE ANALOGS | BOOJAMRA CONSTANTINE G | 2010-01-28 | — | — | US | disclosed |
| US-20090181930-A1 | KINASE INHIBITORY PHOSPHONATE ANALOGS | CANNIZZARO CARINA | 2009-07-16 | — | — | US | disclosed |
| US-7452901-B2 | Anti-cancer phosphonate analogs | GILEAD SCIENCES, INC. (US) | 2008-11-18 | — | — | US | disclosed |
| US-7417055-B2 | Kinase inhibitory phosphonate analogs | GILEAD SCIENCES, INC. (US) | 2008-08-26 | — | — | US | disclosed |
| US-20070281907-A1 | Kinase Inhibitor Phosphonate Conjugates | GILEAD SCIENCES, INC. | 2007-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181930-A1 | KINASE INHIBITORY PHOSPHONATE ANALOGS | PIK3CA, PNKP, PIK3CB | SRC 503/4885KDR 860/4885EGFR 802/4885 |
| US-20100022467-A1 | ANTI-CANCER PHOSPHONATE ANALOGS | PIK3CA, PHOSPHO1, PTEN | SRC 823/4885KDR 1628/4885EGFR 493/4885 |
| US-20070281907-A1 | Kinase Inhibitor Phosphonate Conjugates | PIK3CA, PNKP, PLK1 | SRC 235/4885KDR 593/4885EGFR 498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.