Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 17/20 | 0.74 |
| ▸ | PREP | P48147 | 2/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.54 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.52 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL665727 | 1.00 | DPP4 (0.74) | DPP4PREPADRB2ADRB1DPP8 | |
| Dimethylamine SCHEMBL4594227 | 0.84 | DPP4 (0.94) | DPP4PREPADRB2ADRB1DPP8 | |
| Dimethylamine SCHEMBL665728 | 0.84 | DPP4 (0.94) | DPP4PREPADRB2ADRB1DPP8 | |
| SCHEMBL4594549 | 0.80 | DPP4 (0.68) | DPP4PREPADRB2ADRB1DPP8 | |
| SCHEMBL666575 | 0.80 | DPP4 (0.68) | DPP4PREPADRB2ADRB1DPP8 | |
| SCHEMBL666938 | 0.75 | DPP4 (0.56) | DPP4PREPDPP8DPP7 | |
| SCHEMBL665335 | 0.71 | DPP4 (0.64) | DPP4PREPDPP8DPP7 | |
| SCHEMBL4594027 | 0.71 | DPP4 (0.64) | DPP4PREPDPP8DPP7 | |
| SCHEMBL4419337 | 0.71 | DPP4 (0.82) | DPP4DPP8 | |
| SCHEMBL4419343 | 0.71 | DPP4 (0.82) | DPP4DPP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1917001-A2 | PHARMACEUTICAL COMPOSITION COMPRISING A DPP-IV INHIBITOR | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007017423-A2 | PHARMACEUTICAL COMPOSITION COMPRISING A DPP-IV INHIBITOR | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-15 | — | — | WO | disclosed |