Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 18/20 | 0.57 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.55 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.49 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL666221 | 1.00 | DPP4 (0.57) | DPP4DPP7DPP8DPP9NPC1 | |
| SCHEMBL662815 | 0.92 | DPP4 (0.59) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL7068756 | 0.90 | DPP4 (0.68) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL666163 | 0.90 | DPP4 (0.68) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL4594423 | 0.87 | DPP4 (0.55) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL667317 | 0.87 | DPP4 (0.55) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL664125 | 0.85 | DPP4 (0.61) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL4593456 | 0.85 | DPP4 (0.61) | DPP4DPP7DPP8DPP9 | |
| SCHEMBL6404619 | 0.84 | NPC1 (0.47) | DPP4NPC1 | |
| SCHEMBL663417 | 0.84 | NPC1 (0.47) | DPP4NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1917001-A2 | PHARMACEUTICAL COMPOSITION COMPRISING A DPP-IV INHIBITOR | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-07 | — | — | EP | disclosed |
| WO-2007017423-A2 | PHARMACEUTICAL COMPOSITION COMPRISING A DPP-IV INHIBITOR | F. HOFFMANN-LA ROCHE AG (CH) | 2007-02-15 | — | — | WO | disclosed |