Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 8/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | DPP4 | P27487 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | PREP | P48147 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL663417 | 1.00 | NPC1 (0.47) | NPC1MEN1KMT2ATP53MAPT | |
| SCHEMBL666152 | 0.90 | DPP4 (0.49) | DPP4PREP | |
| SCHEMBL4857151 | 0.88 | DPP4 (0.51) | DPP4PREP | |
| SCHEMBL665308 | 0.88 | DPP4 (0.51) | DPP4PREP | |
| SCHEMBL665317 | 0.88 | DPP4 (0.53) | DPP4PREP | |
| SCHEMBL664051 | 0.88 | DPP4 (0.45) | DPP4PREP | |
| SCHEMBL664742 | 0.86 | DPP4 (0.46) | MEN1KMT2ATP53MAPTDPP4 | |
| SCHEMBL6829857 | 0.86 | DPP4 (0.46) | MEN1KMT2ATP53MAPTDPP4 | |
| SCHEMBL4594320 | 0.84 | DPP4 (0.57) | NPC1DPP4 | |
| SCHEMBL666221 | 0.84 | DPP4 (0.57) | NPC1DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6861440-B2 | DPP IV inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2005-03-01 | — | — | US | disclosed |