SCHEMBL4594345

SCHEMBL4594345

OCC(O)COc1ccc2oc(NC3CCNCC3)nc2c1

nearest known ligand 0.43

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HDAC6 Q9UBN7 1/20 0.43
PDE3B Q13370 1/20 0.40
PDE3A Q14432 1/20 0.40
P2RY12 Q9H244 1/20 0.40
SSTR5 P35346 6/20 0.38
FAAH O00519 4/20 0.38
KCNH2 Q12809 1/20 0.38
FGFR1 P11362 1/20 0.37
KDR P35968 1/20 0.37
TLR9 Q9NR96 1/20 0.36
TLR7 Q9NYK1 1/20 0.36
SSTR1 P30872 1/20 0.36
IRAK4 Q9NWZ3 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL1121547 0.93 HDAC6 (0.42) HDAC6PDE3BPDE3AP2RY12SSTR5
SCHEMBL1121548 0.84 HDAC6 (0.39) HDAC6SSTR5FAAHKCNH2KDR
Hydrochloric Acid SCHEMBL1121926 0.84 TLR7 (0.43) HDAC6SSTR5FAAHKCNH2KDR
Hydrochloric Acid SCHEMBL1121509 0.83 TLR7 (0.43) HDAC6PDE3BPDE3AP2RY12SSTR5
SCHEMBL4594314 0.81 SSTR5 (0.46) HDAC6SSTR5FAAHKCNH2TLR9
SCHEMBL1121777 0.80 HDAC6 (0.46) HDAC6SSTR5FAAHKCNH2KDR
SCHEMBL1121855 0.80 FAAH (0.44) HDAC6SSTR5FAAHKCNH2TLR9
SCHEMBL1121582 0.80 HDAC6 (0.45) HDAC6SSTR5FAAHKCNH2KDR
SCHEMBL1121588 0.79 FAAH (0.44) HDAC6SSTR5FAAHKDRTLR9
SCHEMBL1121546 0.79 FAAH (0.52) HDAC6SSTR5FAAHIRAK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1924579-A2 BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES F.HOFFMANN-LA ROCHE AG (CH) 2008-05-28 EP disclosed
WO-2007025897-A2 BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2007-03-08 WO disclosed