Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 8/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 7/20 | 0.38 |
| ▸ | SSTR5 | P35346 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | CETP | P11597 | 3/20 | 0.33 |
| ▸ | CTSL | P07711 | 2/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4594459 | 0.88 | SSTR5 (0.35) | SLC6A2SLC6A4SLC6A3SSTR5KCNH2 | |
| SCHEMBL5488609 | 0.88 | SSTR5 (0.41) | SLC6A2SLC6A4SLC6A3SSTR5IKBKB | |
| SCHEMBL4593627 | 0.87 | SSTR5 (0.39) | SLC6A2SLC6A4SLC6A3SSTR5KCNH2 | |
| SCHEMBL4593937 | 0.85 | SSTR5 (0.38) | SLC6A2SLC6A4SLC6A3SSTR5KCNH2 | |
| SCHEMBL4593544 | 0.85 | SSTR5 (0.46) | SSTR5KCNH2 | |
| SCHEMBL1380236 | 0.84 | SSTR5 (0.54) | SSTR5KCNH2 | |
| SCHEMBL5489076 | 0.84 | SSTR5 (0.46) | SLC6A2SLC6A4SLC6A3SSTR5KCNH2 | |
| SCHEMBL4593907 | 0.84 | SSTR5 (0.37) | SLC6A2SLC6A4SLC6A3SSTR5KCNH2 | |
| SCHEMBL4594591 | 0.84 | GAA (0.42) | SSTR5KCNH2 | |
| SCHEMBL4593823 | 0.83 | SSTR5 (0.37) | SLC6A2SLC6A4SLC6A3SSTR5KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924579-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-05-28 | — | — | EP | disclosed |
| EP-1858901-A1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | F. Hoffmann-La Roche AG (CH) | 2007-11-28 | — | — | EP | disclosed |
| WO-2007025897-A2 | BENZOOXAZOLE, OXAZOLOPYRIDINE, BENZOTHIAZOLE AND THIAZOLOPYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-03-08 | — | — | WO | disclosed |
| WO-2006094682-A1 | BENZOTHIAZOLE, THIAZOLOPYRIDINE, BENZOOXAZOLE AND OXAZOLOPYRIDINE DERIVATIVES AS ANTIDIABETIC COMPOUNDS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-09-14 | — | — | WO | disclosed |