Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 8/20 | 0.68 |
| ▸ | PIM1 | P11309 | 11/20 | 0.64 |
| ▸ | PIM2 | Q9P1W9 | 8/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.63 |
| ▸ | FLT3 | P36888 | 1/20 | 0.60 |
| ▸ | FYN | P06241 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4333488 | 0.91 | FYN (0.70) | RETPIM1PIM2KCNH2FLT3 | |
| SCHEMBL4339484 | 0.88 | RET (0.70) | RETPIM1PIM2KCNH2FYN | |
| SCHEMBL4345213 | 0.87 | RET (0.72) | RETPIM1PIM2FYN | |
| SCHEMBL4594844 | 0.85 | RET (0.72) | RETPIM1PIM2FLT3FYN | |
| SCHEMBL4337283 | 0.83 | PIM1 (0.67) | RETPIM1PIM2KCNH2FLT3 | |
| SCHEMBL14308667 | 0.83 | RET (0.68) | RETPIM1PIM2FYN | |
| SCHEMBL4342746 | 0.82 | RET (0.76) | RETPIM1PIM2FYN | |
| SCHEMBL4339010 | 0.80 | PIM1 (0.69) | RETPIM1PIM2KCNH2FYN | |
| SCHEMBL4330227 | 0.79 | PIM1 (0.65) | PIM1PIM2KCNH2FLT3FYN | |
| SCHEMBL22421504 | 0.78 | PIM1 (0.81) | PIM1PIM2KCNH2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080039455-A1 | PYRAZOLOPYRIMIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2008-02-14 | — | — | US | claimed |
| EP-1873157-A1 | Pyrazolopyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same | Bayer Schering Pharma Aktiengesellschaft (DE) | 2008-01-02 | — | — | EP | claimed |
| US-20080039455-A1 | PYRAZOLOPYRIMIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2008-02-14 | — | — | US | disclosed |
| EP-1873157-A1 | Pyrazolopyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same | Bayer Schering Pharma Aktiengesellschaft (DE) | 2008-01-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039455-A1 | PYRAZOLOPYRIMIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME | DPYD, FLT1, PDXK | RET 911/4885PIM1 400/4885PIM2 424/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.