Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 8/20 | 0.61 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.53 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.50 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.49 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 4/20 | 0.41 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4595051 | 0.85 | PIK3CG (0.70) | FYNPIK3CGTGFBR2TGFBR1ACVR2A | |
| SCHEMBL4836241 | 0.83 | FYN (0.60) | FYNPIK3CGTGFBR2TGFBR1ACVR2A | |
| SCHEMBL4325907 | 0.82 | PIK3CG (0.64) | FYNPIK3CGTGFBR2TGFBR1ACVR2A | |
| SCHEMBL4334657 | 0.81 | FYN (0.66) | FYNPIK3CGTGFBR2TGFBR1ACVR2A | |
| SCHEMBL4330157 | 0.80 | PIK3CG (0.60) | FYNPIK3CGTGFBR2TGFBR1ACVR2A | |
| SCHEMBL4594646 | 0.79 | PIM1 (0.66) | FYNPIK3CGTGFBR2TGFBR1ACVR2A | |
| SCHEMBL4333317 | 0.79 | MAPT (0.57) | FYNPIK3CGTGFBR2TGFBR1ACVR2A | |
| SCHEMBL4338374 | 0.79 | PIK3CG (0.71) | FYNPIK3CGTGFBR2TGFBR1ACVR2A | |
| SCHEMBL4333357 | 0.78 | FYN (0.71) | FYNPIK3CGTGFBR2TGFBR1ACVR2A | |
| SCHEMBL4559449 | 0.78 | PIK3CG (0.77) | FYNPIK3CGTGFBR2TGFBR1ACVR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1873157-A1 | Pyrazolopyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same | Bayer Schering Pharma Aktiengesellschaft (DE) | 2008-01-02 | — | — | EP | disclosed |