Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 9/20 | 0.66 |
| ▸ | PIM2 | Q9P1W9 | 5/20 | 0.66 |
| ▸ | FYN | P06241 | 3/20 | 0.64 |
| ▸ | RET | P07949 | 4/20 | 0.61 |
| ▸ | KDR | P35968 | 1/20 | 0.54 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.49 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.46 |
| ▸ | ACVR2A | P27037 | 1/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.45 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4333345 | 0.90 | PIM1 (0.71) | PIM1PIM2FYNRETKDR | |
| SCHEMBL4334657 | 0.87 | FYN (0.66) | PIM1PIM2FYNRETKDR | |
| SCHEMBL4594911 | 0.84 | PIM1 (0.76) | PIM1PIM2FYNRETKDR | |
| SCHEMBL4331236 | 0.83 | PIM1 (0.64) | PIM1PIM2FYNRETKDR | |
| SCHEMBL4327436 | 0.80 | FYN (0.80) | PIM1FYNRETPIK3CG | |
| SCHEMBL4595051 | 0.80 | PIK3CG (0.70) | PIM1FYNRETPIK3CGTGFBR2 | |
| SCHEMBL4338989 | 0.80 | PIM1 (0.69) | PIM1PIM2RETKDR | |
| SCHEMBL4332411 | 0.79 | PIM1 (1.00) | PIM1PIM2RETKDR | |
| Ammonia Solution, Strong SCHEMBL4594648 | 0.79 | FYN (0.61) | PIM1PIM2FYNPIK3CGTGFBR2 | |
| SCHEMBL4885901 | 0.79 | FYN (0.52) | PIM1PIM2FYNRETKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080039455-A1 | PYRAZOLOPYRIMIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME | BAYER INTELLECTUAL PROPERTY GMBH (DE) | 2008-02-14 | — | — | US | claimed |
| EP-1873157-A1 | Pyrazolopyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same | Bayer Schering Pharma Aktiengesellschaft (DE) | 2008-01-02 | — | — | EP | claimed |
| EP-1873157-A1 | Pyrazolopyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same | Bayer Schering Pharma Aktiengesellschaft (DE) | 2008-01-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039455-A1 | PYRAZOLOPYRIMIDINES AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME | DPYD, FLT1, PDXK | PIM1 400/4885PIM2 424/4885FYN 151/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.