Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 8/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.39 |
| ▸ | PKM | P14618 | 3/20 | 0.38 |
| ▸ | PKLR | P30613 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | ULK1 | O75385 | 2/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | CDK7 | P50613 | 1/20 | 0.34 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.34 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4595080 | 0.80 | KIF11 (0.40) | KIF11PTGS2PKMPKLRPTGS1 | |
| SCHEMBL4897585 | 0.78 | KIF11 (0.58) | KIF11PKMPKLRGAA | |
| SCHEMBL4888989 | 0.75 | KIF11 (0.68) | KIF11PKMPKLRAKT1ULK1 | |
| SCHEMBL4596680 | 0.75 | KIF11 (0.68) | KIF11PKMPKLR | |
| SCHEMBL4899215 | 0.74 | KIF11 (0.62) | KIF11AKT1 | |
| SCHEMBL4888035 | 0.73 | KIF11 (0.86) | KIF11PKMPKLRAKT1 | |
| SCHEMBL4899973 | 0.72 | KIF11 (0.61) | KIF11PKM | |
| SCHEMBL4888861 | 0.71 | KIF11 (0.86) | KIF11PKMPKLRAKT1 | |
| SCHEMBL1396616 | 0.70 | KIF11 (1.00) | KIF11PKMPKLRAKT1 | |
| SCHEMBL4893622 | 0.70 | KIF11 (0.47) | KIF11PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874753-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | claimed |
| WO-2006113432-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | claimed |