Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 6/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 4/20 | 0.38 |
| ▸ | SMPD3 | Q9NY59 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MTOR | P42345 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4333739 | 0.80 | RET (0.43) | FYNMEN1KMT2ANPC1RAB9A | |
| SCHEMBL4333742 | 0.79 | FYN (0.45) | FYNMEN1KMT2ANPC1RAB9A | |
| SCHEMBL4595306 | 0.74 | FYN (0.63) | FYNMEN1KMT2ACYP1A2CYP3A4 | |
| SCHEMBL4335186 | 0.70 | RET (0.42) | FYNMEN1KMT2ANPC1RAB9A | |
| SCHEMBL20081017 | 0.69 | FYN (0.64) | FYNMEN1KMT2ANPC1RAB9A | |
| SCHEMBL4335188 | 0.69 | FYN (0.35) | FYNMEN1KMT2ARET | |
| SCHEMBL4339355 | 0.68 | CETP (0.37) | FYNMEN1KMT2ANPC1RAB9A | |
| SCHEMBL4339353 | 0.67 | RET (0.40) | FYNMAPTSMN1; SMN2SMPD3LMNA | |
| SCHEMBL4331236 | 0.67 | PIM1 (0.64) | FYNMEN1KMT2ATGFBR2RET | |
| SCHEMBL4344874 | 0.66 | FYN (0.61) | FYNMEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1873157-A1 | Pyrazolopyrimidines and salts thereof, pharmaceutical compositions comprising same, methods of preparing same and uses of same | Bayer Schering Pharma Aktiengesellschaft (DE) | 2008-01-02 | — | — | EP | disclosed |