Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 16/20 | 0.66 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.65 |
| ▸ | KDR | P35968 | 3/20 | 0.65 |
| ▸ | EGFR | P00533 | 1/20 | 0.65 |
| ▸ | IGF1R | P08069 | 1/20 | 0.65 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.65 |
| ▸ | SRC | P12931 | 1/20 | 0.65 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.65 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.65 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.65 |
| ▸ | CDK2 | P24941 | 1/20 | 0.65 |
| ▸ | CSK | P41240 | 1/20 | 0.65 |
| ▸ | JAK3 | P52333 | 1/20 | 0.65 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.65 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.52 |
| ▸ | FLT4 | P35916 | 1/20 | 0.52 |
| ▸ | FLT3 | P36888 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4594818 | 0.87 | AURKA (0.76) | AURKAAURKBKDREGFRIGF1R | |
| SCHEMBL5174881 | 0.84 | AURKB (0.75) | AURKAAURKBKDREGFRIGF1R | |
| SCHEMBL5046866 | 0.84 | AURKA (0.75) | AURKAAURKBKDREGFRIGF1R | |
| SCHEMBL5025165 | 0.80 | AURKA (0.87) | AURKAAURKBKDREGFRIGF1R | |
| SCHEMBL4595690 | 0.79 | AURKA (0.63) | AURKAAURKBKDREGFRIGF1R | |
| SCHEMBL5045267 | 0.79 | AURKB (0.91) | AURKAAURKBKDREGFRIGF1R | |
| SCHEMBL31060166 | 0.79 | AURKB (1.00) | AURKAAURKBKDREGFRIGF1R | |
| SCHEMBL5045154 | 0.79 | AURKB (1.00) | AURKAAURKBKDREGFRIGF1R | |
| SCHEMBL5045676 | 0.78 | AURKB (0.88) | AURKAAURKBKDREGFRIGF1R | |
| SCHEMBL5046027 | 0.78 | AURKB (0.85) | AURKAAURKBKDREGFRIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948651-A1 | THIAZOLE ANALOGUES AND USES THEREOF | 4SC AG (DE) | 2008-07-30 | — | — | EP | disclosed |
| WO-2007054357-A1 | THIAZOLE ANALOGUES AND USES THEREOF | 4SC AG (DE) | 2007-05-18 | — | — | WO | disclosed |