Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 10/20 | 0.76 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.64 |
| ▸ | FLT4 | P35916 | 3/20 | 0.64 |
| ▸ | FLT3 | P36888 | 1/20 | 0.64 |
| ▸ | KDR | P35968 | 4/20 | 0.64 |
| ▸ | EGFR | P00533 | 3/20 | 0.64 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.64 |
| ▸ | IGF1R | P08069 | 1/20 | 0.64 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.64 |
| ▸ | SRC | P12931 | 1/20 | 0.64 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.64 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.64 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.64 |
| ▸ | CDK2 | P24941 | 1/20 | 0.64 |
| ▸ | CSK | P41240 | 1/20 | 0.64 |
| ▸ | JAK3 | P52333 | 1/20 | 0.64 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.64 |
| ▸ | LCK | P06239 | 1/20 | 0.59 |
| ▸ | FBP1 | P09467 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4595690 | 0.91 | AURKA (0.63) | AURKAKDREGFRAURKBIGF1R | |
| SCHEMBL5174881 | 0.89 | AURKB (0.75) | AURKAPDGFRBFLT4FLT3KDR | |
| SCHEMBL4595372 | 0.87 | AURKA (0.66) | AURKAPDGFRBFLT4FLT3KDR | |
| SCHEMBL5025165 | 0.86 | AURKA (0.87) | AURKAPDGFRBFLT4FLT3KDR | |
| SCHEMBL13399788 | 0.84 | AURKA (0.83) | AURKAPDGFRBFLT4FLT3KDR | |
| SCHEMBL5045454 | 0.82 | AURKA (0.78) | AURKAPDGFRBFLT4FLT3KDR | |
| SCHEMBL5049573 | 0.82 | AURKA (0.78) | AURKAPDGFRBFLT4FLT3KDR | |
| SCHEMBL5049569 | 0.82 | AURKA (0.78) | AURKAPDGFRBFLT4FLT3KDR | |
| SCHEMBL5046866 | 0.82 | AURKA (0.75) | AURKAPDGFRBFLT4FLT3KDR | |
| SCHEMBL5049592 | 0.81 | AURKA (0.81) | AURKAPDGFRBFLT4FLT3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1948651-A1 | THIAZOLE ANALOGUES AND USES THEREOF | 4SC AG (DE) | 2008-07-30 | — | — | EP | disclosed |
| US-20070149523-A1 | Thiazole Analogues and Uses Thereof | 4SC AG (DE) | 2007-06-28 | — | — | US | disclosed |
| US-20070149523-A1 | Thiazole Analogues and Uses Thereof | 4SC AG (DE) | 2007-06-28 | — | — | US | disclosed |
| US-20070149523-A1 | Thiazole Analogues and Uses Thereof | 4SC AG (DE) | 2007-06-28 | — | — | US | disclosed |
| WO-2007054357-A1 | THIAZOLE ANALOGUES AND USES THEREOF | 4SC AG (DE) | 2007-05-18 | — | — | WO | disclosed |
| WO-2007054357-A1 | THIAZOLE ANALOGUES AND USES THEREOF | 4SC AG (DE) | 2007-05-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149523-A1 | Thiazole Analogues and Uses Thereof | NR3C2, SLC26A4, CLIC4 | AURKA 2397/4885PDGFRB 708/4885FLT4 366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.