Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WDR5 | P61964 | 1/20 | 0.54 |
| ▸ | LDHA | P00338 | 1/20 | 0.53 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.49 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.49 |
| ▸ | CDC25B | P30305 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30021791 | 0.87 | WDR5 (0.58) | WDR5LDHANR4A1NR4A2NR4A3 | |
| SCHEMBL8817410 | 0.84 | WDR5 (0.54) | WDR5LDHANR4A1NR4A2NR4A3 | |
| SCHEMBL5481094 | 0.84 | KDM4E (0.57) | WDR5LDHANR4A1NR4A2NR4A3 | |
| SCHEMBL11504333 | 0.83 | WDR5 (0.53) | WDR5LDHANR4A1NR4A2NR4A3 | |
| SCHEMBL1681386 | 0.83 | WDR5 (0.53) | WDR5LDHANR4A1NR4A2NR4A3 | |
| SCHEMBL27382944 | 0.81 | WDR5 (0.59) | WDR5LDHANR4A1NR4A2NR4A3 | |
| SCHEMBL3927980 | 0.81 | CXCR2 (0.58) | WDR5LDHANR4A1NR4A2NR4A3 | |
| SCHEMBL7081142 | 0.80 | HDAC3 (0.52) | WDR5LDHANR4A1NR4A2NR4A3 | |
| SCHEMBL11782233 | 0.80 | SLC2A1 (0.50) | WDR5LDHANR4A1NR4A2NR4A3 | |
| SCHEMBL7746816 | 0.80 | CNR2 (0.54) | WDR5LDHANR4A1NR4A2NR4A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937657-A1 | N-[1 ,3,4]-THIADIAZOL-2-YL-BENZENE SULFONAMIDES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | Sanofi-Aventis (FR) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007039175-A1 | N-[1 ,3,4]-THIADIAZOL-2-YL-BENZENE SULFONAMIDES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS | SANOFI-AVENTIS (DE) | 2007-04-12 | — | — | WO | disclosed |