Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 7/20 | 0.49 |
| ▸ | EGFR | P00533 | 11/20 | 0.48 |
| ▸ | KDR | P35968 | 7/20 | 0.48 |
| ▸ | AURKA | O14965 | 6/20 | 0.48 |
| ▸ | FLT4 | P35916 | 5/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.48 |
| ▸ | TEK | Q02763 | 5/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.48 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.47 |
| ▸ | FLT1 | P17948 | 2/20 | 0.47 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.47 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | KIF5B | P33176 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3951597 | 0.88 | EGFR (0.48) | KITEGFRKDRAURKAFLT4 | |
| SCHEMBL30891810 | 0.79 | KDR (0.55) | KITEGFRKDRAURKAFLT4 | |
| SCHEMBL26101967 | 0.79 | KDR (0.55) | KITEGFRKDRAURKAFLT4 | |
| Hydrochloric Acid SCHEMBL26101705 | 0.78 | KDR (0.56) | KITEGFRKDRAURKAFLT4 | |
| Hydrochloric Acid SCHEMBL30394719 | 0.78 | KDR (0.56) | KITEGFRKDRAURKAFLT4 | |
| Hydrochloric Acid SCHEMBL4493507 | 0.77 | AURKA (0.54) | EGFRKDRAURKAFLT4PDGFRB | |
| SCHEMBL4423943 | 0.77 | EHMT2 (0.59) | KITEGFRKDRAURKAFLT4 | |
| SCHEMBL3952952 | 0.77 | AURKA (0.51) | EGFRKDRAURKAFLT4PDGFRB | |
| Hydrochloric Acid SCHEMBL2191376 | 0.76 | AURKA (0.51) | EGFRKDRAURKAFLT4PDGFRB | |
| SCHEMBL30891798 | 0.74 | EGFR (0.61) | KITEGFRKDRAURKAFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885719-A1 | 2,5- AND 2,6-DISUBSTITUTED BENZAZOLE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | 4SC AG (DE) | 2008-02-13 | — | — | EP | disclosed |
| WO-2006066795-A1 | 2,5- AND 2,6-DISUBSTITUTED BENZAZOLE DERIVATIVES USEFUL AS PROTEIN KINASE INHIBITORS | 4SC AG (DE) | 2006-06-29 | — | — | WO | disclosed |