Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 20/20 | 0.83 |
| ▸ | CCR2 | P41597 | 3/20 | 0.68 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL225551 | 0.91 | ROCK2 (1.00) | ROCK2CCR2ROCK1 | |
| SCHEMBL2801924 | 0.91 | ROCK2 (1.00) | ROCK2CCR2ROCK1 | |
| SCHEMBL225552 | 0.91 | ROCK2 (1.00) | ROCK2CCR2ROCK1 | |
| SCHEMBL459600 | 0.90 | ROCK2 (0.83) | ROCK2CCR2ROCK1 | |
| SCHEMBL2799870 | 0.86 | ROCK2 (1.00) | ROCK2CCR2ROCK1 | |
| SCHEMBL2802469 | 0.86 | ROCK2 (1.00) | ROCK2CCR2ROCK1 | |
| SCHEMBL220847 | 0.86 | ROCK2 (1.00) | ROCK2CCR2ROCK1 | |
| SCHEMBL659308 | 0.86 | ROCK2 (1.00) | ROCK2CCR2ROCK1 | |
| SCHEMBL220848 | 0.86 | ROCK2 (1.00) | ROCK2CCR2ROCK1 | |
| SCHEMBL461409 | 0.86 | ROCK2 (1.00) | ROCK2CCR2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2595665-A1 | BIFUNCTIONAL RHO KINASE INHIBITOR COMPOUNDS, COMPOSITION AND USE | Inspire Pharmaceuticals, Inc. (US) | 2013-05-29 | — | — | EP | disclosed |
| WO-2012012282-A1 | BIFUNCTIONAL RHO KINASE INHIBITOR COMPOUNDS, COMPOSITION AND USE | INSPIRE PHARMACEUTICALS, INC. (US) | 2012-01-26 | — | — | WO | disclosed |