Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 13/20 | 0.47 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | AKT1 | P31749 | 2/20 | 0.34 |
| ▸ | TPH1 | P17752 | 1/20 | 0.32 |
| ▸ | ULK1 | O75385 | 1/20 | 0.31 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.31 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | CDK2 | P24941 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4893622 | 0.81 | KIF11 (0.47) | KIF11TDP2 | |
| SCHEMBL4594888 | 0.80 | KIF11 (0.56) | KIF11TDP2AKT1PDE3BPDE3A | |
| SCHEMBL4899215 | 0.76 | KIF11 (0.62) | KIF11TDP2AKT1DDB1CRBN | |
| SCHEMBL4887887 | 0.73 | KIF11 (0.55) | KIF11TDP2AKT1PDE3BPDE3A | |
| SCHEMBL4595128 | 0.73 | KIF11 (0.50) | KIF11TDP2 | |
| SCHEMBL3310186 | 0.72 | KIF11 (0.70) | KIF11ULK1PDE3BPDE3A | |
| SCHEMBL4596418 | 0.71 | KIF11 (0.55) | KIF11TDP2AKT1PDE3BPDE3A | |
| SCHEMBL4596412 | 0.71 | KIF11 (0.55) | KIF11TDP2AKT1PDE3BPDE3A | |
| SCHEMBL4893178 | 0.71 | KIF11 (0.63) | KIF11TDP2 | |
| SCHEMBL4596404 | 0.70 | KIF11 (0.44) | KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874753-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-01-09 | — | — | EP | claimed |
| WO-2006113432-A2 | COMPOUNDS, COMPOSITIONS AND METHODS | SMITHKLINE BEECHAM CORPORATION (US) | 2006-10-26 | — | — | WO | claimed |