SCHEMBL4596157

SCHEMBL4596157

C=CC(=O)OCCCCO[Si](C)(C)C

nearest known ligand 0.69

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
TSHR P16473 9/20 0.69
ALDH1A1 P00352 5/20 0.69
CYP3A4 P08684 2/20 0.69
HPGD P15428 1/20 0.62
TP53 P04637 3/20 0.52
HIF1A Q16665 3/20 0.52
HSD17B10 Q99714 1/20 0.52
THRB P10828 2/20 0.43
MAPK1 P28482 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42
ATM Q13315 1/20 0.41
HCAR2 Q8TDS4 4/20 0.39
MAPT P10636 1/20 0.32
RAB9A P51151 1/20 0.32
NPSR1 Q6W5P4 1/20 0.32
NAAA Q02083 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3293446 0.96 TSHR (0.63) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL11803424 0.91 TSHR (0.57) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL476966 0.88 TSHR (0.61) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL1469631 0.85 TSHR (0.60) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL7759302 0.85 TSHR (0.60) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL244114 0.85 TSHR (0.95) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL30450181 0.84 TSHR (0.63) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL30450231 0.84 TSHR (0.63) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL8864051 0.83 TSHR (0.62) TSHRALDH1A1CYP3A4HPGDTP53
SCHEMBL9101988 0.83 TSHR (1.00) TSHRALDH1A1CYP3A4HPGDTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1137727-B1 AQUEOUS COATING COMPOSITIONS DU PONT (US) 2008-01-09 EP disclosed
EP-1619225-A2 Aqueous pigment dispersion E.I.Du pont de nemours and company (US) 2006-01-25 EP disclosed
EP-0996689-B1 PIGMENT DISPERSIONS CONTAINING HYDROXYLATED AB-BLOCK POLYMER DISPERSANT DU PONT (US) 2002-12-18 EP disclosed
US-6306521-B1 SUBSTRATE COATED WITH DRIED, CURED LAYER OF COMPOSITION OF ORGANIC LIQUID CARRIER, FILM FORMING BINDER AND PIGMENT DISPERSION, WHEREIN PIGMENT DISPERSION COMPRISES DISPERSED PIGMENT, CARRIER LIQUID AND AB-BLOCK POLYMER DISPERSANT E. I. DU PONT DE NEMOURS AND COMPANY 2001-10-23 US disclosed
EP-1137727-A1 AQUEOUS COATING COMPOSITIONS E.I. DU PONT DE NEMOURS AND COMPANY (US) 2001-10-04 EP disclosed
US-6204319-B1 AB BLOCK COPOLYMER PIGMENT DISPERSANT RESIN OF AN A BLOCK OF A HYDROPHOBIC POLYMER HAVING AMINE GROUPS; AND A B BLOCK OF A HYDROPHILIC POLYMER HAVING HYDROXYL GROUPS AND CARBOXYL GROUPS E.I. DU PONT DE NEMOURS AND COMPANY 2001-03-20 US disclosed
US-6187854-B1 WEATHERPROOF COATINGS E. I. DU PONT DE NEMOURS AND COMPANY 2001-02-13 US disclosed
WO-2000026308-A1 AQUEOUS COATING COMPOSITIONS E.I. DU PONT DE NEMOURS AND COMPANY (US) 2000-05-11 WO disclosed
EP-0996689-A1 PIGMENT DISPERSIONS CONTAINING HYDROXYLATED AB-BLOCK POLYMER DISPERSANT E.I. DU PONT DE NEMOURS AND COMPANY (US) 2000-05-03 EP disclosed
US-5945483-A High solids content resin composition, high solids content type paint, and painting process using the same DAINIPPON INK AND CHEMICALS, INC. (JP) 1999-08-31 US disclosed
WO-1999003938-A1 PIGMENT DISPERSIONS CONTAINING HYDROXYLATED AB-BLOCK POLYMER DISPERSANT E.I. DU PONT DE NEMOURS AND COMPANY (US) 1999-01-28 WO disclosed
US-5859113-A COATINGS; POLYMER A SEGMENT CONSISTS OF POLYMERIZED GLYCIDYL (METH)ACRYLATE REACTED WITH AN ACID; POLYMER B SEGMENT CONTAINS REACTIVE HYDROXY ALKYL (METH)ACRYLATE MONOMERS E. I. DU PONT DE NEMOURS AND COMPANY (US) 1999-01-12 US disclosed
US-5705567-A High solids content resin composition, high solids content type paint, and painting process using the same DAINIPPON INK AND CHEMICALS, INC. (JP) 1998-01-06 US disclosed
US-5658988-A ONE-PACKAGE; AUTOMOBILE FINISHES KANSAI PAINT CO., LTD. (JP) 1997-08-19 US disclosed
US-3935342-A POLYMERIZATION WITH AN UNSATURATED SILYL MONOMER MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DT) 1976-01-27 US disclosed