Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 | P07550 | 20/20 | 0.78 |
| ▸ | ADRB1 | P08588 | 20/20 | 0.78 |
| ▸ | DRD2 | P14416 | 12/20 | 0.78 |
| ▸ | DRD3 | P35462 | 2/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4526560 | 0.88 | ADRB2 (1.00) | ADRB2ADRB1DRD2DRD3ADRA1D | |
| SCHEMBL4514497 | 0.84 | ADRB2 (0.79) | ADRB2ADRB1DRD2DRD3ADRA1D | |
| SCHEMBL4514502 | 0.84 | ADRB2 (0.79) | ADRB2ADRB1DRD2DRD3ADRA1D | |
| SCHEMBL4596275 | 0.83 | ADRB2 (0.73) | ADRB2ADRB1DRD2DRD3 | |
| SCHEMBL13711697 | 0.80 | ADRB2 (0.72) | ADRB2ADRB1DRD2DRD3ADRA1D | |
| SCHEMBL4518404 | 0.77 | ADRB2 (1.00) | ADRB2ADRB1DRD2DRD3ADRA1D | |
| Hydrochloric Acid SCHEMBL4514960 | 0.76 | ADRB2 (0.98) | ADRB2ADRB1DRD2DRD3ADRA1D | |
| SCHEMBL4521381 | 0.76 | ADRB2 (1.00) | ADRB2ADRB1DRD2DRD3ADRA1D | |
| SCHEMBL4529805 | 0.76 | ADRB2 (1.00) | ADRB2ADRB1DRD2DRD3ADRA1D | |
| SCHEMBL4519610 | 0.76 | ADRB2 (0.73) | ADRB2ADRB1DRD2ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937656-A1 | 7-(2-AMINO-1-HYDROXY-ETHYL)-4-HYDROXYBENZOTHIAZOL-2(3H)-ONE-DERIVATIVES AS BETA 2 ADRENOCEPTOR AGONISTS | AstraZeneca AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007027134-A1 | 7-(2-AMINO-1-HYDROXY-ETHYL)-4-HYDROXYBENZOTHIAZOL-2(3H)-ONE-DERIVATIVES AS β2 ADRENOCEPTOR AGONISTS | ASTRAZENECA AB (SE) | 2007-03-08 | — | — | WO | disclosed |