Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.72 |
| ▸ | GRM5 | P41594 | 1/20 | 0.71 |
| ▸ | CLPP | Q16740 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | TSHR | P16473 | 4/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.68 |
| ▸ | LMNA | P02545 | 3/20 | 0.68 |
| ▸ | HTT | P42858 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.68 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4152495 | 0.85 | GRM5 (0.73) | HSD11B1GRM5CLPPMEN1KMT2A | |
| SCHEMBL4136800 | 0.85 | GRM5 (0.73) | HSD11B1GRM5CLPPMEN1KMT2A | |
| SCHEMBL4136792 | 0.85 | GRM5 (0.73) | HSD11B1GRM5CLPPMEN1KMT2A | |
| SCHEMBL4152490 | 0.85 | GRM5 (0.73) | HSD11B1GRM5CLPPMEN1KMT2A | |
| SCHEMBL4151228 | 0.84 | MEN1 (0.82) | HSD11B1GRM5CLPPMEN1KMT2A | |
| SCHEMBL4144196 | 0.84 | HSD11B1 (0.85) | HSD11B1GRM5CLPPMEN1KMT2A | |
| SCHEMBL4151222 | 0.84 | MEN1 (0.82) | HSD11B1GRM5CLPPMEN1KMT2A | |
| SCHEMBL4144201 | 0.84 | HSD11B1 (0.85) | HSD11B1GRM5CLPPMEN1KMT2A | |
| SCHEMBL4144889 | 0.84 | GRM5 (0.71) | HSD11B1GRM5CLPPMEN1KMT2A | |
| SCHEMBL4144892 | 0.84 | GRM5 (0.71) | HSD11B1GRM5CLPPMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896463-A2 | NOVEL OXADIAZOLE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX Pharma S.A. (CH) | 2008-03-12 | — | — | EP | disclosed |
| WO-2006123249-A2 | NOVEL OXADIAZOLE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA SA (CH) | 2006-11-23 | — | — | WO | disclosed |