Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 6/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.37 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.37 |
| ▸ | PRCP | P42785 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | G6PC1 | P35575 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29987608 | 1.00 | CES1 (0.40) | CES1CYP11B2CYP3A4CYP17A1KDM4E | |
| SCHEMBL5119030 | 0.86 | CYP3A4 (0.42) | CES1CYP11B2CYP3A4CYP17A1KDM4E | |
| Cadaverine Tartrate SCHEMBL30208244 | 0.85 | SRD5A1 (0.36) | CES1CYP11B2CYP3A4CYP17A1KDM4E | |
| SCHEMBL13384396 | 0.85 | CYP3A4 (0.41) | CES1CYP11B2CYP3A4CYP17A1NPC1 | |
| SCHEMBL16340167 | 0.85 | NPC1 (0.42) | CES1CYP11B2CYP3A4CYP17A1NPC1 | |
| SCHEMBL4132334 | 0.85 | CYP11B2 (0.56) | CYP11B2CYP3A4CYP17A1NPC1RAB9A | |
| SCHEMBL7077942 | 0.84 | TDP1 (0.41) | CYP11B2CYP3A4CYP17A1NPC1MAPT | |
| SCHEMBL6069049 | 0.83 | SRD5A2 (0.51) | CES1NPC1MAPTRAB9A | |
| SCHEMBL28208839 | 0.81 | SRD5A1 (0.38) | CES1CYP11B2CYP17A1RAB9ACYP11B1 | |
| SCHEMBL21559837 | 0.81 | NPC1 (0.39) | CYP11B2CYP3A4CYP17A1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115894146-A | Synthetic method of 3-bromo-1-phenylnaphthalene | 上海固创化工新材料有限公司 | 2023-04-04 | — | — | CN | claimed |
| US-20150252134-A1 | SWELL INDEX OF HIPS USING ADDITIVES | FINA TECHNOLOGY (US) | 2015-09-10 | — | — | US | claimed |
| US-9090715-B2 | Swell index of HIPS using additives | FINA TECHNOLOGY, INC. (US) | 2015-07-28 | — | — | US | claimed |
| US-20120252975-A1 | Swell Index of HIPS Using Additives | FINA TECHNOLOGY, INC. (US) | 2012-10-04 | — | — | US | claimed |
| WO-2012134952-A1 | IMPROVEMENT OF SWELL INDEX OF HIPS USING ADDITIVES | FINA TECHNOLOGY, INC. (US) | 2012-10-04 | — | — | WO | claimed |
| US-20070161681-A1 | ETHER DERIVATIVES USEFUL AS INHIBITORS OF PDE4 ISOZYMES | PFIZER INC. (US) | 2007-07-12 | — | — | US | claimed |
| US-20030027845-A1 | Ether derivatives useful as inhibitors of PDE4 isozymes | PFIZER INC. | 2003-02-06 | — | — | US | claimed |
| CN-115093308-B | Synthesis method of 1-bromo-4-phenyl naphthalene | 上海固创化工新材料有限公司 | 2024-03-22 | — | — | CN | disclosed |
| CN-115894146-A | Synthetic method of 3-bromo-1-phenylnaphthalene | 上海固创化工新材料有限公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-115894146-A | Synthetic method of 3-bromo-1-phenylnaphthalene | 上海固创化工新材料有限公司 | 2023-04-04 | — | — | CN | disclosed |
| CN-115844877-A | Use of lasofoxifene to modulate membrane-bound estrogen signaling and methods of treating cancer | 王巍 | 2023-03-28 | — | — | CN | disclosed |
| CN-115737636-A | Use of lasofoxifene to modulate membrane-bound estrogen signaling and methods of treating cancer | 王巍 | 2023-03-07 | — | — | CN | disclosed |
| CN-115737637-A | Use of lasofoxifene to modulate membrane-bound estrogen signaling and methods of treating cancer | 王巍 | 2023-03-07 | — | — | CN | disclosed |
| EP-1373258-A1 | ETHER DERIVATIVES USEFUL AS INHIBITORS OF PDE4 ISOZYMES | Pfizer Products Inc. (US) | 2004-01-02 | — | — | EP | disclosed |
| WO-2003102202-A2 | PROCESS FOR PREPARING VINYLAROMATIC COMPOUNDS | DSM IP ASSETS B.V. (NL) | 2003-12-11 | — | — | WO | disclosed |
| US-6608212-B1 | Palladium catalyzed coupling of a vinylphosphate and aryl-metal halide; preparation of such as 1-(4-(2-(pyrrolidin-n-yl)-ethoxy)phenyl)-6-methoxy-3,4-dihydronaphthalene | PFIZER, INC. | 2003-08-19 | — | — | US | disclosed |
| US-20030027845-A1 | Ether derivatives useful as inhibitors of PDE4 isozymes | PFIZER INC. | 2003-02-06 | — | — | US | disclosed |
| WO-2002060896-A1 | ETHER DERIVATIVES USEFUL AS INHIBITORS OF PDE4 ISOZYMES | PFIZER PRODUCTS INC. (US) | 2002-08-08 | — | — | WO | disclosed |
| EP-0374824-B1 | DENTAL COMPOSITIONS CONTAINING BIFUNCTIONAL ACRYLIC OR METHACRYLIC ACID ESTERS | THERA Patent GmbH & Co. KG Gesellschaft für industrielle Schutzrechte (DE) | 1993-09-22 | — | — | EP | disclosed |
| EP-0374824-A2 | Dental compositions containing bifunctional acrylic or methacrylic acid esters | THERA Patent GmbH & Co. KG Gesellschaft für industrielle Schutzrechte (DE) | 1990-06-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070161681-A1 | ETHER DERIVATIVES USEFUL AS INHIBITORS OF PDE4 ISOZYMES | PDE4A, PDE4B, PDE4D | CES1 168/4885CYP11B2 113/4885CYP3A4 67/4885 |
| US-20030027845-A1 | Ether derivatives useful as inhibitors of PDE4 isozymes | CBR1, PDE4A, PDE4B | CES1 77/4885CYP11B2 58/4885CYP3A4 544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.