Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Levamfetamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.63 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.63 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.63 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.63 |
| ▸ | MAOA | P21397 | 1/20 | 0.63 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.63 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.63 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.63 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.63 |
| ▸ | ALPI | P09923 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.62 |
| ▸ | XIAP | P98170 | 1/20 | 0.62 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.62 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.58 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.58 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.58 |
| ▸ | CPA1 | P15085 | 2/20 | 0.54 |
| ▸ | CPB1 | P15086 | 1/20 | 0.54 |
| ▸ | CPA3 | P15088 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dextroamphetamine SCHEMBL3681578 | 1.00 | SLC6A2 (0.63) | SLC6A2TAAR1SLC6A4MAOASLC6A3 | |
| Amphetamine SCHEMBL1030967 | 1.00 | SLC6A2 (0.63) | SLC6A2TAAR1SLC6A4MAOASLC6A3 | |
| Amphetamine SCHEMBL1030966 | 1.00 | SLC6A2 (0.63) | SLC6A2TAAR1SLC6A4MAOASLC6A3 | |
| Amphetamine SCHEMBL19285614 | 0.98 | SLC6A2 (0.61) | SLC6A2TAAR1SLC6A4MAOASLC6A3 | |
| Amphetamine SCHEMBL1005247 | 0.98 | SLC6A2 (0.61) | SLC6A2TAAR1SLC6A4MAOASLC6A3 | |
| Amphetamine SCHEMBL19285616 | 0.98 | SLC6A2 (0.61) | SLC6A2TAAR1SLC6A4MAOASLC6A3 | |
| Amphetamine SCHEMBL30336931 | 0.98 | SLC6A2 (0.61) | SLC6A2TAAR1SLC6A4MAOASLC6A3 | |
| Levamfetamine SCHEMBL30083110 | 0.98 | SLC6A2 (0.61) | SLC6A2TAAR1SLC6A4MAOASLC6A3 | |
| Dextroamphetamine SCHEMBL21158800 | 0.98 | SLC6A2 (0.61) | SLC6A2TAAR1SLC6A4MAOASLC6A3 | |
| Amphetamine SCHEMBL1005248 | 0.98 | SLC6A2 (0.61) | SLC6A2TAAR1SLC6A4MAOASLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9713592-B2 | Matrix-based pulse release pharmaceutical formulation | MALLINCKRODT LLC (US) | 2017-07-25 | — | — | US | claimed |
| EP-1874274-A2 | MATRIX-BASED PULSE RELEASE PHARMACEUTICAL FORMULATION | MALLINCKRODT INC. (US) | 2008-01-09 | — | — | EP | claimed |
| WO-2006107593-A2 | MATRIX-BASED PULSE RELEASE PHARMACEUTICAL FORMULATION | MALLINCKRODT INC. (US) | 2006-10-12 | — | — | WO | claimed |
| EP-1874274-A2 | MATRIX-BASED PULSE RELEASE PHARMACEUTICAL FORMULATION | MALLINCKRODT INC. (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2006107593-A2 | MATRIX-BASED PULSE RELEASE PHARMACEUTICAL FORMULATION | MALLINCKRODT INC. (US) | 2006-10-12 | — | — | WO | disclosed |