Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14222840 | 0.83 | MAP2K1 (0.44) | DHODHMAPTKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL4595156 | 0.82 | DHODH (0.56) | DHODHMAPTKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL14222851 | 0.78 | MAP2K1 (0.42) | DHODHMAPTKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL4596340 | 0.75 | MAP2K1 (0.64) | MAP2K1EGFR | |
| SCHEMBL14222842 | 0.75 | MAP2K1 (0.48) | DHODHNPC1RAB9AMAP2K1 | |
| SCHEMBL14219627 | 0.73 | MAP2K1 (0.43) | DHODHMAPTKMT2ASMN1; SMN2NPC1 | |
| SCHEMBL14219608 | 0.73 | DHODH (0.54) | DHODHMAP2K1LMNAEGFR | |
| SCHEMBL14219808 | 0.72 | DHODH (0.53) | DHODHMAPTKMT2ANPC1RAB9A | |
| SCHEMBL4596558 | 0.72 | MAP2K1 (0.60) | MAP2K1 | |
| SCHEMBL4596552 | 0.72 | MAP2K1 (0.60) | MAP2K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008041088-A2 | N-HYDROXY BENZAMIDES WITH ANTITUMOR ACTIVITY | EOS (ETHICAL ONCOLOGY SCIENCE) S.P.A. (IT) | 2008-04-10 | — | — | WO | disclosed |
| EP-1908751-A1 | N-hydroxy benzamides with antitumour activity | EOS S.p.A. (IT) | 2008-04-09 | — | — | EP | disclosed |