Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 4/20 | 0.56 |
| ▸ | MAP2K1 | Q02750 | 2/20 | 0.55 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.49 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | XDH | P47989 | 1/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | CLCN2 | P51788 | 2/20 | 0.38 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.38 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14222837 | 0.87 | DHODH (0.54) | DHODHMAP2K1MAP2K2SORT1EGFR | |
| SCHEMBL14219608 | 0.87 | DHODH (0.54) | DHODHMAP2K1MAP2K2EGFRCLCN2 | |
| SCHEMBL14219808 | 0.87 | DHODH (0.53) | DHODHMAP2K1SORT1NPC1MAPT | |
| SCHEMBL14223199 | 0.85 | DHODH (0.51) | DHODHMAP2K1SORT1SMN1; SMN2NPC1 | |
| SCHEMBL14222840 | 0.83 | MAP2K1 (0.44) | DHODHMAP2K1MAP2K2SMN1; SMN2NPC1 | |
| SCHEMBL4596768 | 0.82 | DHODH (0.42) | DHODHMAP2K1SMN1; SMN2NPC1MAPT | |
| SCHEMBL14222842 | 0.82 | MAP2K1 (0.48) | DHODHMAP2K1MAP2K2NPC1RAB9A | |
| SCHEMBL14220140 | 0.81 | MAP2K1 (0.51) | DHODHMAP2K1MAP2K2 | |
| SCHEMBL14222834 | 0.81 | MAP2K1 (0.49) | DHODHMAP2K1MAP2K2KMT2AEGFR | |
| SCHEMBL14222851 | 0.81 | MAP2K1 (0.42) | DHODHMAP2K1MAP2K2SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008041088-A2 | N-HYDROXY BENZAMIDES WITH ANTITUMOR ACTIVITY | EOS (ETHICAL ONCOLOGY SCIENCE) S.P.A. (IT) | 2008-04-10 | — | — | WO | disclosed |
| WO-2008041088-A2 | N-HYDROXY BENZAMIDES WITH ANTITUMOR ACTIVITY | EOS (ETHICAL ONCOLOGY SCIENCE) S.P.A. (IT) | 2008-04-10 | — | — | WO | disclosed |
| EP-1908751-A1 | N-hydroxy benzamides with antitumour activity | EOS S.p.A. (IT) | 2008-04-09 | — | — | EP | disclosed |
| EP-1908751-A1 | N-hydroxy benzamides with antitumour activity | EOS S.p.A. (IT) | 2008-04-09 | — | — | EP | disclosed |