SCHEMBL4596985

SCHEMBL4596985

CC1CN(c2ccc(C#N)c(Cl)c2)C(C)CN1

nearest known ligand 0.52

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AR P10275 17/20 0.52
TRPV4 Q9HBA0 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3560395 1.00 AR (0.52) ARTRPV4
SCHEMBL4596989 1.00 AR (0.52) ARTRPV4
SCHEMBL23134696 1.00 AR (0.52) ARTRPV4
SCHEMBL30588443 1.00 AR (0.52) ARTRPV4
SCHEMBL4597254 0.88 AR (0.38) AR
SCHEMBL3568982 0.88 AR (0.38) AR
SCHEMBL4597253 0.88 AR (0.38) AR
SCHEMBL6859327 0.85 AR (0.36) AR
SCHEMBL6859331 0.85 AR (0.36) AR
SCHEMBL13269795 0.85 AR (0.36) AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040010037-A1 Cyanophenyl derivative YAMANOUCHI PHARMACEUTICAL CO., LTD. 2004-01-15 US claimed
CN-114761003-B Novel ureas having androgen receptor degrading activity and uses thereof 冰洲石生物科技公司 2023-12-29 CN disclosed
US-20230150973-A1 NOVEL UREAS HAVING ANDROGEN RECEPTOR DEGRADATION ACTIVITY AND USES THEREOF ACCUTAR BIOTECHNOLOGY INC. (US) 2023-05-18 US disclosed
US-11420956-B2 Ureas having Androgen Receptor degradation activity and uses thereof ACCUTAR BIOTECHNOLOGY INC. (US) 2022-08-23 US disclosed
CN-114761003-A Novel ureas having androgen receptor degrading activity and use thereof 冰洲石生物科技公司 2022-07-15 CN disclosed
US-11220490-B2 Ureas having androgen receptor degradation activity and uses thereof ACCUTAR BIOTECHNOLOGY INC. (US) 2022-01-11 US disclosed
US-20210300901-A1 NOVEL UREAS HAVING ANDROGEN RECEPTOR DEGRADATION ACTIVITY AND USES THEREOF ACCUTAR BIOTECHNOLOGY INC. (US) 2021-09-30 US disclosed
US-20210087170-A1 NOVEL UREAS HAVING ANDROGEN RECEPTOR DEGRADATION ACTIVITY AND USES THEREOF ACCUTAR BIOTECHNOLOGY INC. (US) 2021-03-25 US disclosed
EP-1122242-B1 CYANOPHENYL DERIVATIVES ASTELLAS PHARMA INC (JP) 2008-01-16 EP disclosed
US-20040010037-A1 Cyanophenyl derivative YAMANOUCHI PHARMACEUTICAL CO., LTD. 2004-01-15 US disclosed
US-6673799-B1 INHIBITS BINDING TO ANDROGEN RECEPTOR; ANTIANDROGEN YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 2004-01-06 US disclosed
EP-1122242-A1 CYANOPHENYL DERIVATIVES YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 2001-08-08 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11420956-B2 Ureas having Androgen Receptor degradation activity and uses thereof AR, UTS2R, ESRRA AR 1/4885TRPV4 3866/4885
US-20040010037-A1 Cyanophenyl derivative BPHL, AR, KLK3 AR 2/4885TRPV4 2659/4885
US-20210300901-A1 NOVEL UREAS HAVING ANDROGEN RECEPTOR DEGRADATION ACTIVITY AND USES THEREOF AR, UTS2R, ESRRA AR 1/4885TRPV4 3927/4885
US-11220490-B2 Ureas having androgen receptor degradation activity and uses thereof AR, UTS2R, ESRRA AR 1/4885TRPV4 3866/4885
US-20210087170-A1 NOVEL UREAS HAVING ANDROGEN RECEPTOR DEGRADATION ACTIVITY AND USES THEREOF AR, UTS2R, ESRRA AR 1/4885TRPV4 3927/4885
US-20230150973-A1 NOVEL UREAS HAVING ANDROGEN RECEPTOR DEGRADATION ACTIVITY AND USES THEREOF AR, UTS2R, ESRRA AR 1/4885TRPV4 3927/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.