Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AQP1 | P29972 | 2/20 | 0.55 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.45 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.45 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.45 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.45 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.45 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.45 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 5/20 | 0.39 |
| ▸ | HTR7 | P34969 | 5/20 | 0.39 |
| ▸ | HTR2A | P28223 | 4/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 3/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4595447 | 0.91 | AQP1 (0.54) | AQP1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4597068 | 0.87 | AQP1 (0.60) | AQP1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4595087 | 0.87 | AQP1 (0.57) | AQP1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4229927 | 0.86 | AQP1 (0.51) | AQP1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4219199 | 0.86 | AQP1 (0.67) | AQP1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4226529 | 0.85 | AQP1 (0.54) | AQP1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4596812 | 0.84 | AQP1 (0.58) | AQP1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4225466 | 0.84 | AQP1 (0.61) | AQP1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4230508 | 0.84 | AQP1 (0.61) | AQP1PRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL4226249 | 0.83 | AQP1 (0.52) | AQP1PRKAB2PRKAG1PRKAA2PRKAA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874750-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth Incoporated (US) | 2008-01-09 | — | — | EP | disclosed |
| WO-2007030150-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH (US) | 2007-03-15 | — | — | WO | disclosed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | disclosed |