Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C8 | P10632 | 1/20 | 0.65 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.60 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.60 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.60 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.60 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.60 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.60 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.58 |
| ▸ | RXRA | P19793 | 1/20 | 0.57 |
| ▸ | RXRB | P28702 | 1/20 | 0.57 |
| ▸ | RXRG | P48443 | 1/20 | 0.57 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
| ▸ | KDM1A | O60341 | 1/20 | 0.56 |
| ▸ | APP | P05067 | 1/20 | 0.51 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | P2RY14 | Q15391 | 2/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2268521 | 0.85 | CYP2C8 (0.60) | CYP2C8PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL2428750 | 0.85 | CYP2C8 (0.56) | CYP2C8SRD5A2RXRARXRBRXRG | |
| SCHEMBL5937246 | 0.84 | CYP2C8 (0.58) | CYP2C8PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL27867340 | 0.83 | TP53 (0.55) | CYP2C8SRD5A2RXRARXRB | |
| SCHEMBL6264068 | 0.82 | AKR1C3 (0.54) | CYP2C8SRD5A2RXRARXRBRXRG | |
| SCHEMBL21274227 | 0.82 | AKR1C3 (0.64) | CYP2C8SRD5A2RXRARXRBRXRG | |
| SCHEMBL27883746 | 0.81 | TP53 (0.52) | CYP2C8SRD5A2RXRARXRB | |
| SCHEMBL505133 | 0.81 | SRD5A2 (0.77) | CYP2C8SRD5A2RXRARXRBRXRG | |
| SCHEMBL5171097 | 0.81 | PSEN1 (0.51) | CYP2C8PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL5171104 | 0.81 | PSEN1 (0.51) | CYP2C8PSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080300261-A1 | Arylacetic Acids and Related Compounds for Treatment of Alzheimer's Disease | MERCK SHARP & DOHME LTD. (GB) | 2008-12-04 | — | — | US | disclosed |
| EP-1773315-B1 | ARYLACETIC ACIDS AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (GB) | 2008-01-16 | — | — | EP | disclosed |
| EP-1773315-A1 | ARYLACETIC ACIDS AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | Merck Sharp & Dohme Limited (GB) | 2007-04-18 | — | — | EP | disclosed |
| WO-2006008558-A1 | ARYLACETIC ACIDS AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER’S DISEASE | MERCK SHARP & DOHME LIMITED (GB) | 2006-01-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080300261-A1 | Arylacetic Acids and Related Compounds for Treatment of Alzheimer's Disease | PSEN2, PSEN1, NAT1 | CYP2C8 1257/4885PSEN1 2/4885PSEN2 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.