⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24473252 | 0.90 | ALDH1A1 (0.33) | — | |
| SCHEMBL1930515 | 0.86 | — | — | |
| SCHEMBL1928641 | 0.86 | — | — | |
| SCHEMBL13212989 | 0.85 | ALDH1A1 (0.42) | — | |
| SCHEMBL5125852 | 0.83 | ALDH1A1 (0.52) | — | |
| SCHEMBL14533550 | 0.83 | ALDH1A1 (0.52) | — | |
| SCHEMBL10029791 | 0.83 | ALDH1A1 (0.52) | — | |
| SCHEMBL12866832 | 0.83 | ALDH1A1 (0.52) | — | |
| SCHEMBL860505 | 0.83 | — | — | |
| SCHEMBL16137665 | 0.83 | ALDH1A1 (0.52) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 528 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024064178-A1 | HEXAHYDRO-2H-PYRIDO[2,1-A]ISOQUINOLINE VMAT2 INHIBITORS AND METHODS OF USE | NEUROCRINE BIOSCIENCES, INC. (US) | 2024-03-28 | — | — | WO | claimed |
| CN-117062815-A | VMAT2 inhibitors and methods of use | 纽罗克里生物科学有限公司 | 2023-11-14 | — | — | CN | claimed |
| EP-4168409-A1 | VMAT2 INHIBITORS AND METHODS OF USE | Neurocrine Biosciences, Inc. (US) | 2023-04-26 | — | — | EP | claimed |
| WO-2017157991-A1 | 1-ALKYL-PYRAZOLES AND -INDAZOLES AS BUB1 INHIBITORS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2017-09-21 | — | — | WO | claimed |
| US-20160046620-A1 | METHODS OF CONTROLLING NEONICOTINOID RESISTANT PESTS | SYNGENTA LIMITED (GB) | 2016-02-18 | — | — | US | claimed |
| EP-2978318-A1 | METHODS OF CONTROLLING NEONICOTINOID RESISTANT PESTS | Syngenta Participations AG (CH) | 2016-02-03 | — | — | EP | claimed |
| WO-2014154487-A1 | METHODS OF CONTROLLING NEONICOTINOID RESISTANT PESTS | SYNGENTA PARTICIPATIONS AG (CH) | 2014-10-02 | — | — | WO | claimed |
| US-20080176865-A1 | SUBSTITUTED ARYLPYRAZOLES | PFIZER LIMITED (GB) | 2008-07-24 | — | — | US | claimed |
| US-20070149550-A1 | 1-aryl-4-cyclopropylpyrazoles with at least one fluorine attached to the cyclopropyl ring; parasiticides; fleas; extended duration of action for at least 28 days | PFIZER INC. (US) | 2007-06-28 | — | — | US | claimed |
| EP-4747258-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS | Tenvie Therapeutics, Inc. (US) | 2026-05-27 | — | — | EP | disclosed |
| WO-2025024329-A2 | COMPOUNDS, COMPOSITIONS, AND METHODS | NICO THERAPEUTICS, INC. (US) | 2025-01-30 | — | — | WO | disclosed |
| US-12209102-B2 | Heterocyclic compounds and uses thereof | KUMQUAT BIOSCIENCES INC. (US) | 2025-01-28 | — | — | US | disclosed |
| EP-4489738-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | Kumquat Biosciences Inc. (US) | 2025-01-15 | — | — | EP | disclosed |
| US-20240425525-A1 | HETEROCYCLIC COMPOUNDS AND USES THEREOF | KUMQUAT BIOSCIENCES INC. | 2024-12-26 | — | — | US | disclosed |
| US-4720593-A | Process for the production of 1-methylcyclopropanecarboxaldehyde | DEGUSSA AKTIENGESELLSCHAFT (DE) | 1988-01-19 | — | — | US | disclosed |
| EP-0227415-A2 | Pyrimidine derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1987-07-01 | — | — | EP | disclosed |
| EP-0219652-A2 | Process for the preparation of 1-methylcyclopropanecarboxaldehyde | Degussa Aktiengesellschaft (DE) | 1987-04-29 | — | — | EP | disclosed |
| US-4444764-A | INSECTICIDES | THE DOW CHEMICAL COMPANY (US) | 1984-04-24 | — | — | US | disclosed |
| EP-0023841-B1 | 5 PYRIMIDINOL PHOSPHORUS ESTERS, AND METHODS FOR THEIR MANUFACTURE, COMPOSITIONS CONTAINING THOSE ESTERS AND THEIR USE AS PESTICIDES | THE DOW CHEMICAL COMPANY (US) | 1984-03-21 | — | — | EP | disclosed |
| EP-0023841-A2 | 5 Pyrimidinol phosphorus esters, and methods for their manufacture, compositions containing those esters and their use as pesticides | THE DOW CHEMICAL COMPANY (US) | 1981-02-11 | — | — | EP | disclosed |