Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 3/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 7/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 4/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.35 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4596424 | 0.88 | PARP1 (0.37) | PARP1GRM2MAOBMAOA | |
| SCHEMBL4608666 | 0.86 | PARP1 (0.40) | PARP1MAOBMAOA | |
| SCHEMBL4597503 | 0.85 | MAOB (0.35) | GRM2HTR2AMAOBHSD11B1TDP2 | |
| SCHEMBL4596409 | 0.85 | PARP1 (0.39) | PARP1GRM2MAOBMAOA | |
| SCHEMBL4713241 | 0.84 | PARP1 (0.49) | PARP1GRM2HTR2APDE3BPDE3A | |
| SCHEMBL4234539 | 0.82 | AQP1 (0.51) | GRM2HTR2AMAOBTDP2ADORA1 | |
| SCHEMBL4219997 | 0.82 | AQP1 (0.53) | GRM2HTR2AMAOBHSD11B1TDP2 | |
| SCHEMBL4220005 | 0.81 | AQP1 (0.42) | GRM2MAOBTDP2ADORA1ADORA2A | |
| SCHEMBL4712018 | 0.81 | AQP1 (0.40) | PARP1GRM2HTR2APDE3BPDE3A | |
| SCHEMBL4596869 | 0.80 | PARP1 (0.43) | PARP1GRM2HTR2AMAOBPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2007509174-A | — | — | 2007-04-12 | — | — | JP | claimed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | claimed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | claimed |
| EP-1874750-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth Incoporated (US) | 2008-01-09 | — | — | EP | disclosed |
| EP-1675840-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005044812-A1 | DIHYDROBENZOFURANYL ALKANAMINE DERIVATIVES AS 5HT2C AGONISTS | WYETH A CORPORATION OF THE STATE OF DELAWARE (US) | 2005-05-19 | — | — | WO | disclosed |