Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | LIPE | Q05469 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3914828 | 0.86 | DRD2 (0.39) | SMN1; SMN2RAB9AALDH1A1DRD2DRD4 | |
| SCHEMBL3921081 | 0.85 | DRD2 (0.40) | ALDH1A1DRD2DRD4SIGMAR1LMNA | |
| SCHEMBL3912115 | 0.85 | DRD2 (0.40) | ALDH1A1DRD2DRD4SIGMAR1LMNA | |
| SCHEMBL3914146 | 0.83 | KDM4E (0.46) | SMN1; SMN2RAB9AALDH1A1NPC1SIGMAR1 | |
| SCHEMBL3912803 | 0.83 | KDM4E (0.46) | SMN1; SMN2RAB9AALDH1A1NPC1SIGMAR1 | |
| SCHEMBL3924819 | 0.79 | CNR2 (0.37) | DRD2DRD4 | |
| SCHEMBL3936339 | 0.79 | EPHX2 (0.37) | RAB9AALDH1A1DRD2DRD4EPHX2 | |
| SCHEMBL3925482 | 0.78 | DPP4 (0.38) | RAB9AALDH1A1DRD2DRD4EPHX2 | |
| SCHEMBL3936344 | 0.76 | KDM4E (0.38) | SMN1; SMN2RAB9AALDH1A1DRD2DRD4 | |
| SCHEMBL3933234 | 0.74 | DRD2 (0.35) | SMN1; SMN2ALDH1A1DRD2DRD4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907374-A2 | COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007012479-A2 | BENZYLPIPERAZINE DERIVATES AND THEIR MEDICAL USE | GLAXO GROUP LIMITED (GB) | 2007-02-01 | — | — | WO | disclosed |