Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 4/20 | 0.49 |
| ▸ | KIT | P10721 | 1/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.42 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4560141 | 0.81 | CSF1R (0.60) | CSF1RKITFGFR1FGFR4MET | |
| SCHEMBL4560772 | 0.75 | GPR84 (0.47) | CSF1RKITFGFR1FGFR4MET | |
| SCHEMBL4560845 | 0.75 | CYP3A4 (0.47) | CSF1RKITFGFR1FGFR4MET | |
| SCHEMBL1267123 | 0.70 | CSF1R (0.62) | CSF1RKITFGFR1FGFR4MET | |
| SCHEMBL14147656 | 0.69 | FGFR1 (0.64) | CSF1RKITFGFR1FGFR4MET | |
| SCHEMBL413742 | 0.69 | CSF1R (0.56) | CSF1RKITFGFR1FGFR4MET | |
| SCHEMBL4605793 | 0.69 | CYP3A4 (0.43) | CSF1RKITHTR2ABRD4CDK2 | |
| SCHEMBL15279127 | 0.69 | CSF1R (0.72) | CSF1RKITFGFR1FGFR4MET | |
| SCHEMBL1266304 | 0.68 | CSF1R (0.62) | CSF1RKITFGFR1FGFR4MET | |
| SCHEMBL1267706 | 0.68 | CSF1R (0.79) | CSF1RKITFGFR1FGFR4MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008064265-A2 | COMPOUNDS MODULATING C-FMS AND/OR C-KIT ACTIVITY AND USES THEREFOR | PLEXXIKON, INC. (US) | 2008-05-29 | — | — | WO | disclosed |