Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 2/20 | 0.55 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.55 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.55 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.55 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.55 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.46 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.46 |
| ▸ | PPARG | P37231 | 4/20 | 0.45 |
| ▸ | PPARA | Q07869 | 3/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28209100 | 0.83 | PPARG (0.58) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL28471837 | 0.82 | PPARG (0.47) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1154169 | 0.81 | LDHA (0.55) | PTGS1PTGS2FFAR1PPARGPPARA | |
| SCHEMBL9110619 | 0.78 | PSEN1 (0.46) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3004987 | 0.78 | PPARG (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL491402 | 0.78 | PSEN1 (0.90) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL491339 | 0.78 | PSEN1 (0.90) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL4038598 | 0.77 | PSEN1 (0.61) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL14087362 | 0.77 | PTPN5 (0.59) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL28440688 | 0.77 | FFAR1 (0.59) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1993120-B | Arylacetic acids and related compounds for treatment of alzheimer's disease | MERCK SHARP & DOHME BLURTON PETER | 2010-05-05 | — | — | CN | disclosed |
| US-20080300261-A1 | Arylacetic Acids and Related Compounds for Treatment of Alzheimer's Disease | MERCK SHARP & DOHME LTD. (GB) | 2008-12-04 | — | — | US | disclosed |
| EP-1773315-B1 | ARYLACETIC ACIDS AND RELATED COMPOUNDS FOR TREATMENT OF ALZHEIMER'S DISEASE | MERCK SHARP & DOHME (GB) | 2008-01-16 | — | — | EP | disclosed |
| CN-1993120-A | Arylacetic acids and related compounds for treatment of alzheimer's disease | MERCK SHARP & DOHME BLURTON PE (GB) | 2007-07-04 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080300261-A1 | Arylacetic Acids and Related Compounds for Treatment of Alzheimer's Disease | PSEN2, PSEN1, NAT1 | PSEN1 2/4885PSEN2 1/4885APH1B 69/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.