SCHEMBL459771

SCHEMBL459771

Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(OC[C@H]2O[C@@H](n3cnc4c(N)ncnc43)C(O)C2O)OP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C1O

nearest known ligand 0.84

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
P2RY1 P47900 7/20 0.84
P2RY2 P41231 4/20 0.84
P2RX1 P51575 4/20 0.84
P2RX3 P56373 4/20 0.84
SRC P12931 2/20 0.84
SMN1; SMN2 Q16637 2/20 0.84
P2RX2 Q9UBL9 2/20 0.84
ALDH1A1 P00352 2/20 0.84
P2RX4 Q99571 1/20 0.84
TRPM2 O94759 2/20 0.80
TAS1R3 Q7RTX0 2/20 0.80
TAS1R1 Q7RTX1 2/20 0.80
DNPH1 O43598 1/20 0.80
PRKAB2 O43741 1/20 0.80
LDHA P00338 1/20 0.80
ADRB2 P07550 1/20 0.80
FBP1 P09467 1/20 0.80
ADORA1 P30542 1/20 0.80
PRKAG1 P54619 1/20 0.80
PRKAA2 P54646 1/20 0.80

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL459997 1.00 P2RY1 (0.84) P2RY1P2RY2P2RX1P2RX3SRC
SCHEMBL1746647 1.00 P2RY1 (0.84) P2RY1P2RY2P2RX1P2RX3SRC
SCHEMBL10396861 0.99 P2RY1 (0.86) P2RY1P2RY2P2RX1P2RX3SRC
Water SCHEMBL9225179 0.99 P2RY1 (0.82) P2RY1P2RY2P2RX1P2RX3SRC
SCHEMBL3792441 0.99 P2RY1 (0.82) P2RY1P2RY2P2RX1P2RX3SRC
SCHEMBL5838786 0.99 P2RY1 (0.82) P2RY1P2RY2P2RX1P2RX3SRC
SCHEMBL28646263 0.98 P2RY1 (0.84) P2RY1P2RY2P2RX1P2RX3SRC
SCHEMBL28367704 0.98 P2RY1 (0.84) P2RY1P2RY2P2RX1P2RX3SRC
SCHEMBL6242721 0.98 P2RY1 (0.84) P2RY1P2RY2P2RX1P2RX3SRC
SCHEMBL27962220 0.97 P2RY1 (0.80) P2RY1P2RY2P2RX1P2RX3SRC

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 381 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4600370-A1 NUDE.1 AS A DECAPPING ENZYME FOR COFACTOR- AND \"CANONICALLY\"-CAPPED RNA SPECIES Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. (DE) 2025-08-13 EP claimed
US-20250049894-A1 TREATMENT OF NUDT2 MUTATION UNIV GENEVE (CH) 2025-02-13 US claimed
EP-4408431-A1 TREATMENT OF NUDT2 MUTATION Université de Genève (CH) 2024-08-07 EP claimed
EP-4389214-A2 USE OF TRIMETHOXYBENZYL ACETYLSINAPATE, ADVANTAGEOUSLY IN COMBINATION WITH AT LEAST ONE SUNSCREEN, FOR PROTECTING THE SKIN Thorel, Jean-Noël (FR) 2024-06-26 EP claimed
EP-3466419-B1 USE OF TRIMETHOXYBENZYL ACETYLSINAPATE, ADVANTAGEOUSLY IN COMBINATION WITH AT LEAST ONE SUNSCREEN, FOR PROTECTING THE SKIN THOREL JEAN NOEL (FR) 2024-05-08 EP claimed
CN-117070547-A Application of modified APaH gene in improving expression activity of exogenous gene 齐鲁工业大学(山东省科学院) 2023-11-17 CN claimed
WO-2023052411-A1 TREATMENT OF NUDT2 MUTATION UNIVERSITÉ DE GENÈVE (CH) 2023-04-06 WO claimed
EP-3466419-A1 USE OF TRIMETHOXYBENZYL ACETYLSINAPATE, ADVANTAGEOUSLY IN COMBINATION WITH AT LEAST ONE SUNSCREEN, FOR PROTECTING THE SKIN Thorel, Jean-Noël (FR) 2019-04-10 EP claimed
EP-1581177-B1 CUTANEOUS METABOLIC BIO-ACTIVATOR THOREL JEAN NOEL (FR) 2018-04-11 EP claimed
US-20150369817-A1 PLATELET BIOMARKERS IN CANCER DIAGNOSIS NEOPROTEOMICS AB (SE) 2015-12-24 US claimed
EP-0969848-A1 USE OF DIADENOSINE POLYPHOSPHATES FOR REDUCING BLOOD PRESSURE Clemson University (US) 2000-01-12 EP claimed
WO-1999043326-A1 USE OF A CARDIAC PURINOCEPTOR TO EFFECT CELLULAR GLUCOSE UPTAKE THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 1999-09-02 WO claimed
EP-0721955-B1 Diadenosine tetraphosphate tetrasodium salt dodecahydrate crystals UNITIKA LTD (JP) 1999-04-07 EP claimed
WO-1998030222-A1 USE OF DIADENOSINE POLYPHOSPHATES FOR REDUCING BLOOD PRESSURE CLEMSON UNIVERSITY (US) 1998-07-16 WO claimed
EP-0566140-B1 Method for producing dinucleoside polyphosphate, nucleoside polyphosphate or derivatives thereof UNITIKA LTD (JP) 1998-07-01 EP claimed
US-5306629-A Two-stage reaction using two enzymes: adenosine-5-triphosphate sulfurylase and diadenosine tetraphosphate phosphorylase as catalysts, and adenosine-5-triphosphate, polyphosphate and a sulfate as substrates UNITIKA LTD. (JP) 1994-04-26 US claimed
EP-0566140-A2 Method for producing dinucleoside polyphosphate, nucleoside polyphosphate or derivatives thereof UNITIKA LTD. (JP) 1993-10-20 EP claimed
EP-0247819-B1 PROCESS FOR PRODUCING DIADENOSINE TETRAPHOSPHATE AND DERIVATIVES THEREOF UNITIKA LTD. (JP) 1991-07-24 EP claimed
US-4886749-A Process for producing diadenosine tetraphosphate and derivatives thereof UNITIKA LTD. (JP) 1989-12-12 US claimed
EP-0247819-A2 Process for producing diadenosine tetraphosphate and derivatives thereof UNITIKA LTD. (JP) 1987-12-02 EP claimed