Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.40 |
| ▸ | CDK9 | P50750 | 5/20 | 0.40 |
| ▸ | CDC7 | O00311 | 4/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.40 |
| ▸ | PIM1 | P11309 | 3/20 | 0.40 |
| ▸ | PRKACA | P17612 | 3/20 | 0.40 |
| ▸ | CLK2 | P49760 | 3/20 | 0.40 |
| ▸ | GSK3B | P49841 | 3/20 | 0.40 |
| ▸ | CDK7 | P50613 | 3/20 | 0.40 |
| ▸ | PRKX | P51817 | 3/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.40 |
| ▸ | FLT3 | P36888 | 2/20 | 0.40 |
| ▸ | CDK8 | P49336 | 2/20 | 0.40 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.40 |
| ▸ | MINK1 | Q8N4C8 | 2/20 | 0.40 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL257134 | 0.82 | KMT2A (1.00) | KMT2ACHEK1CDK9CDC7LRRK2 | |
| SCHEMBL29768777 | 0.82 | KMT2A (1.00) | KMT2ACHEK1CDK9CDC7LRRK2 | |
| SCHEMBL29768778 | 0.82 | KMT2A (1.00) | KMT2ACHEK1CDK9CDC7LRRK2 | |
| Alcohol SCHEMBL27754790 | 0.74 | KMT2A (0.82) | KMT2ACHEK1CDK9CDC7LRRK2 | |
| SCHEMBL15331290 | 0.68 | KMT2A (0.71) | KMT2ACHEK1CDK9LRRK2AXL | |
| SCHEMBL15331287 | 0.68 | KMT2A (0.71) | KMT2ACHEK1CDK9LRRK2AXL | |
| SCHEMBL857987 | 0.68 | KMT2A (0.52) | KMT2ACHEK1CDK9CDC7DAPK3 | |
| SCHEMBL858196 | 0.68 | KMT2A (0.52) | KMT2ACHEK1CDK9CDC7DAPK3 | |
| SCHEMBL73686 | 0.67 | — | — | |
| SCHEMBL1772824 | 0.67 | KMT2A (0.69) | KMT2ACHEK1CDK9CDC7MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1885723-A2 | PYRROLO[2,3-B]PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PLEXXIKON, INC. (US) | 2008-02-13 | — | — | EP | disclosed |
| WO-2007013896-A2 | PYRROL (2,3-B) PYRIDINE DERIVATIVES PROTEIN KINASE INHIBITORS | PLEXXIKON, INC. (US) | 2007-02-01 | — | — | WO | disclosed |