Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F10 | P00742 | 17/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14097939 | 1.00 | F10 (0.38) | F10NPC1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL14138802 | 0.92 | F10 (0.36) | F10NPC1CYP2C19RAB9A | |
| SCHEMBL4598104 | 0.90 | F10 (0.48) | F10 | |
| SCHEMBL4598445 | 0.90 | F10 (0.48) | F10 | |
| SCHEMBL14627677 | 0.89 | F10 (0.34) | F10 | |
| SCHEMBL4599259 | 0.89 | F10 (0.51) | F10 | |
| SCHEMBL4604029 | 0.83 | F10 (0.42) | F10 | |
| SCHEMBL4606187 | 0.83 | F10 (0.42) | F10 | |
| SCHEMBL14138393 | 0.82 | F10 (0.41) | F10 | |
| SCHEMBL14627717 | 0.80 | F10 (0.40) | F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907388-A1 | NOVEL HETEROARYL FUSED CYCLIC AMINES | F. Hoffmann-Roche AG (CH) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007009883-A1 | NOVEL HETEROARYL FUSED CYCLIC AMINES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-01-25 | — | — | WO | disclosed |