SCHEMBL4598104

SCHEMBL4598104

Cn1ncc2c1CN(C(=O)Nc1ccc(Cl)cc1)C2C(=O)Nc1ccc(-n2ccncc2=O)cc1F

nearest known ligand 0.48

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
F10 P00742 20/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4598445 1.00 F10 (0.48) F10
SCHEMBL14138393 0.93 F10 (0.41) F10
SCHEMBL14627717 0.91 F10 (0.40) F10
SCHEMBL14097943 0.91 F10 (0.54) F10
SCHEMBL4597237 0.90 F10 (0.60) F10
SCHEMBL4597978 0.90 F10 (0.60) F10
SCHEMBL14097939 0.90 F10 (0.38) F10
SCHEMBL4597813 0.90 F10 (0.38) F10
SCHEMBL4604525 0.85 F10 (0.52) F10
SCHEMBL14138802 0.82 F10 (0.36) F10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1907388-A1 NOVEL HETEROARYL FUSED CYCLIC AMINES F. Hoffmann-Roche AG (CH) 2008-04-09 EP disclosed
WO-2007009883-A1 NOVEL HETEROARYL FUSED CYCLIC AMINES F. HOFFMANN-LA ROCHE AG (CH) 2007-01-25 WO disclosed