Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.43 |
| ▸ | CKS1B | P61024 | 2/20 | 0.41 |
| ▸ | SKP1 | P63208 | 2/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.41 |
| ▸ | KDM4A | O75164 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | ACACB | O00763 | 1/20 | 0.39 |
| ▸ | ACACA | Q13085 | 1/20 | 0.39 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16379594 | 0.81 | CTSK (0.50) | SYKCTSSCTSKKDM4AATM | |
| SCHEMBL15983852 | 0.81 | CTSK (0.50) | SYKCTSSCTSKKDM4AATM | |
| SCHEMBL4597846 | 0.80 | CTSK (0.47) | CTSSCTSKMEN1NPC1RAB9A | |
| SCHEMBL15979342 | 0.79 | SYK (0.48) | SYKCTSSCTSKPCSK9KDM4A | |
| SCHEMBL2726543 | 0.78 | STK17B (0.47) | SYKCTSSCTSKPCSK9CKS1B | |
| SCHEMBL2726540 | 0.78 | STK17B (0.47) | SYKCTSSCTSKPCSK9CKS1B | |
| SCHEMBL20668483 | 0.78 | STK17B (0.47) | SYKCTSSCTSKPCSK9CKS1B | |
| SCHEMBL29678262 | 0.78 | HDAC6 (0.67) | — | |
| SCHEMBL7834971 | 0.78 | CTSK (0.55) | SYKCTSSCTSKKDM4AMEN1 | |
| SCHEMBL6503512 | 0.77 | SYK (0.41) | SYKCTSSCTSKPCSK9CKS1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1924265-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | Genzyme Corporation (US) | 2008-05-28 | — | — | EP | disclosed |
| WO-2007022371-A2 | CHEMOKINE RECEPTOR BINDING COMPOUNDS | GENZYME CORPORATION (US) | 2007-02-22 | — | — | WO | disclosed |