Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 4/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MITF | O75030 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5311017 | 1.00 | HTR1B (0.66) | HTR1BKCNH2POLBKDM4EMAPT | |
| SCHEMBL4250243 | 0.93 | HTR1B (0.71) | HTR1BKCNH2MAPTNPC1RAB9A | |
| SCHEMBL5309015 | 0.92 | HTR1B (0.65) | HTR1BKCNH2KDM4EMAPTNPC1 | |
| SCHEMBL5308451 | 0.90 | HTR1B (0.78) | HTR1BKCNH2KDM4EMAPTNPC1 | |
| SCHEMBL4246714 | 0.89 | HTR1B (0.83) | HTR1BKCNH2POLBKDM4EMAPT | |
| SCHEMBL14529770 | 0.89 | HTR1B (0.66) | HTR1BKCNH2MAPTNPC1RAB9A | |
| SCHEMBL4247598 | 0.88 | HTR1B (0.65) | HTR1BKCNH2POLBKDM4EMAPT | |
| SCHEMBL4248665 | 0.86 | HTR1B (0.62) | HTR1BKCNH2POLBKDM4EMAPT | |
| SCHEMBL4246690 | 0.86 | HTR1B (0.62) | HTR1BKCNH2POLBKDM4EMAPT | |
| SCHEMBL5308292 | 0.84 | HTR1B (0.63) | HTR1BKCNH2POLBMAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1945624-A1 | CHROMAN COMPOUNDS AS 5-HT1B ANTAGONISTS | Astra Zeneca AB (SE) | 2008-07-23 | — | — | EP | disclosed |
| EP-1910340-A1 | INDAZOLECARBOXAMIDE DERIVATIVES AS 5HT4 RECEPTOR AGONISTS | Pfizer, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007053095-A1 | CHROMAN COMPOUNDS AS 5-HT1B ANTAGONISTS | ASTRAZENECA AB (SE) | 2007-05-10 | — | — | WO | disclosed |
| WO-2007010390-A1 | INDAZOLECARBOXAMIDE DERIVATIVES AS 5HT4 RECEPTOR AGONISTS | PFIZER JAPAN INC. (JP) | 2007-01-25 | — | — | WO | disclosed |