Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 9/20 | 0.78 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.78 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4250243 | 0.96 | HTR1B (0.71) | HTR1BKCNH2RAD52MAPTMEN1 | |
| SCHEMBL14529770 | 0.92 | HTR1B (0.66) | HTR1BKCNH2RAD52MAPTMEN1 | |
| SCHEMBL4247598 | 0.91 | HTR1B (0.65) | HTR1BKCNH2ALDH1A1KDM4EMAPT | |
| SCHEMBL5308358 | 0.90 | HTR1B (0.79) | HTR1BKCNH2RAD52ALDH1A1MAPT | |
| SCHEMBL4597945 | 0.90 | HTR1B (0.66) | HTR1BKCNH2ALDH1A1KDM4EMAPT | |
| SCHEMBL5311017 | 0.90 | HTR1B (0.66) | HTR1BKCNH2ALDH1A1KDM4EMAPT | |
| SCHEMBL5309015 | 0.89 | HTR1B (0.65) | HTR1BKCNH2RAD52ALDH1A1KDM4E | |
| SCHEMBL4246690 | 0.89 | HTR1B (0.62) | HTR1BKCNH2ALDH1A1KDM4EMAPT | |
| SCHEMBL4248665 | 0.89 | HTR1B (0.62) | HTR1BKCNH2ALDH1A1KDM4EMAPT | |
| SCHEMBL4247047 | 0.88 | HTR1B (1.00) | HTR1BKCNH2RAD52ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007053093-A1 | CHROMAN COMPOUNDS AS 5 HT1B ANTAGONISTS | ASTRAZENECA AB (SE) | 2007-05-10 | — | — | WO | claimed |
| WO-2020183011-A1 | HTR1D INHIBITORS AND USES THEREOF IN THE TREATMENT OF CANCER | INSTITUT CURIE (FR) | 2020-09-17 | — | — | WO | disclosed |
| WO-2007053093-A1 | CHROMAN COMPOUNDS AS 5 HT1B ANTAGONISTS | ASTRAZENECA AB (SE) | 2007-05-10 | — | — | WO | disclosed |
| WO-2007053093-A1 | CHROMAN COMPOUNDS AS 5 HT1B ANTAGONISTS | ASTRAZENECA AB (SE) | 2007-05-10 | — | — | WO | disclosed |