Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | ANPEP | P15144 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | SI | P14410 | 1/20 | 0.32 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | PPM1B | O75688 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | PPP1CC | P36873 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2081220 | 1.00 | SMYD3 (0.38) | SMYD3CYP1A2ALDH1A1USP2ALOX15 | |
| SCHEMBL2080549 | 0.87 | SMYD3 (0.43) | SMYD3CYP1A2ALDH1A1USP2ALOX15 | |
| SCHEMBL2080551 | 0.87 | SMYD3 (0.43) | SMYD3CYP1A2ALDH1A1USP2ALOX15 | |
| SCHEMBL2080553 | 0.87 | SMYD3 (0.43) | SMYD3CYP1A2ALDH1A1USP2ALOX15 | |
| SCHEMBL4598122 | 0.87 | ALDH1A1 (0.36) | SMYD3CYP1A2ALDH1A1USP2ALOX15 | |
| SCHEMBL2080273 | 0.87 | ALDH1A1 (0.36) | SMYD3CYP1A2ALDH1A1USP2ALOX15 | |
| SCHEMBL2078178 | 0.83 | SRC (0.38) | SMYD3CYP1A2ALDH1A1USP2ALOX15 | |
| SCHEMBL2078091 | 0.78 | USP2 (0.32) | ALDH1A1USP2ALOX15TDP1MMP2 | |
| SCHEMBL2078180 | 0.78 | SMYD3 (0.32) | SMYD3ALDH1A1USP2ALOX15TDP1 | |
| SCHEMBL2080992 | 0.77 | ALDH1A1 (0.38) | SMYD3CYP1A2ALDH1A1USP2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910340-A1 | INDAZOLECARBOXAMIDE DERIVATIVES AS 5HT4 RECEPTOR AGONISTS | Pfizer, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007010390-A1 | INDAZOLECARBOXAMIDE DERIVATIVES AS 5HT4 RECEPTOR AGONISTS | PFIZER JAPAN INC. (JP) | 2007-01-25 | — | — | WO | disclosed |