Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 4/20 | 0.58 |
| ▸ | CLPP | Q16740 | 1/20 | 0.58 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 3/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL193323 | 0.91 | GRM5 (0.70) | GRM5CLPPHSD11B1POLBMEN1 | |
| SCHEMBL193322 | 0.91 | GRM5 (0.70) | GRM5CLPPHSD11B1POLBMEN1 | |
| SCHEMBL2600299 | 0.90 | GRM5 (0.71) | GRM5CLPPHSD11B1POLBMEN1 | |
| SCHEMBL191946 | 0.90 | GRM5 (0.71) | GRM5CLPPHSD11B1POLBMEN1 | |
| SCHEMBL4598470 | 0.85 | GRM5 (0.60) | GRM5CLPPHSD11B1POLBMEN1 | |
| SCHEMBL193948 | 0.82 | HSD11B1 (0.78) | GRM5CLPPHSD11B1POLBMEN1 | |
| SCHEMBL415297 | 0.82 | HSD11B1 (0.78) | GRM5CLPPHSD11B1POLBMEN1 | |
| SCHEMBL4151187 | 0.81 | HSD11B1 (0.80) | GRM5CLPPHSD11B1POLBMEN1 | |
| SCHEMBL4151196 | 0.81 | HSD11B1 (0.80) | GRM5CLPPHSD11B1POLBMEN1 | |
| SCHEMBL4130486 | 0.80 | GRM5 (0.72) | GRM5CLPPHSD11B1POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1896463-A2 | NOVEL OXADIAZOLE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX Pharma S.A. (CH) | 2008-03-12 | — | — | EP | disclosed |
| WO-2006123249-A2 | NOVEL OXADIAZOLE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS | ADDEX PHARMA SA (CH) | 2006-11-23 | — | — | WO | disclosed |