Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.32 |
| ▸ | CTSD | P07339 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3835998 | 0.97 | NR1H4 (0.51) | NR1H4ALDH1A1KDM4EKMT2AATM | |
| SCHEMBL6256758 | 0.93 | NR1H4 (0.50) | NR1H4KMT2AATMCTSD | |
| SCHEMBL3836167 | 0.93 | NR1H4 (0.45) | NR1H4ALDH1A1KDM4EPTPN1CTSD | |
| SCHEMBL5690082 | 0.92 | NR1H4 (0.48) | NR1H4ALDH1A1KDM4EKMT2AATM | |
| SCHEMBL5387987 | 0.91 | NR1H4 (0.38) | NR1H4ALDH1A1KDM4EKMT2A | |
| SCHEMBL5721660 | 0.91 | NR1H4 (0.45) | NR1H4ALDH1A1KDM4EPTPN1CTSD | |
| SCHEMBL5709140 | 0.90 | NR1H4 (0.47) | NR1H4ALDH1A1KDM4EKMT2AATM | |
| SCHEMBL5709061 | 0.90 | NR1H4 (0.47) | NR1H4ALDH1A1KDM4EKMT2AATM | |
| SCHEMBL4598864 | 0.89 | NR1H4 (0.47) | NR1H4ALDH1A1KDM4EKMT2AATM | |
| SCHEMBL3833715 | 0.89 | NR1H4 (0.45) | NR1H4ALDH1A1KDM4ECTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2770990-A1 | BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF HYPERCHOLEMIA AND CHOLESTATIC LIVER DISEASE | Lumena Pharmaceuticals, Inc. (US) | 2014-09-03 | — | — | EP | claimed |
| EP-2771003-A1 | BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF PEDIATRIC CHOLESTATIC LIVER DISEASES | Lumena Pharmaceuticals, Inc. (US) | 2014-09-03 | — | — | EP | claimed |
| WO-2013063512-A1 | BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF PEDIATRIC CHOLESTATIC LIVER DISEASES | LUMENA PHARMACEUTICALS, INC (US) | 2013-05-02 | — | — | WO | claimed |
| WO-2013063526-A1 | BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF HYPERCHOLEMIA AND CHOLESTATIC LIVER DISEASE | Lumena Pharmaceuticals, Inc. (US) | 2013-05-02 | — | — | WO | claimed |
| EP-1877373-A2 | BIPHENYLAZETIDINONE CHOLESTEROL ABSORPTION INHIBITORS | Microbia, Inc. (US) | 2008-01-16 | — | — | EP | disclosed |
| EP-1851197-A2 | PHENYLAZETIDINONE DERIVATIVES | Microbia, Inc. (US) | 2007-11-07 | — | — | EP | disclosed |
| WO-2006121861-A2 | BIPHENYLAZETIDINONE CHOLESTEROL ABSORPTION INHIBITORS | MICROBIA, INC. (US) | 2006-11-16 | — | — | WO | disclosed |
| WO-2006086562-A2 | PHENYLAZETIDINONE DERIVATIVES | MICROBIA, INC. (US) | 2006-08-17 | — | — | WO | disclosed |
| EP-1539120-A1 | COMBINATION OF AN IBAT INHIBITOR AND A METAL SALT FOR THE TREATMENT OF DIARRHOEA | Astrazeneca AB (SE) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004006899-A1 | COMBINATION OF AN IBAT INHIBITOR AND A METAL SALT FOR THE TREATMENT OF DIARRHOEA | ASTRAZENECA AB (SE) | 2004-01-22 | — | — | WO | disclosed |