Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5709061 | 0.94 | NR1H4 (0.47) | NR1H4ALDH1A1KDM4EKMT2AATM | |
| SCHEMBL3835998 | 0.91 | NR1H4 (0.51) | NR1H4ALDH1A1KDM4EKMT2AATM | |
| SCHEMBL4598602 | 0.90 | NR1H4 (0.49) | NR1H4ALDH1A1KDM4EKMT2AATM | |
| SCHEMBL6256758 | 0.90 | NR1H4 (0.50) | NR1H4KMT2AATM | |
| SCHEMBL5690082 | 0.89 | NR1H4 (0.48) | NR1H4ALDH1A1KDM4EKMT2AATM | |
| SCHEMBL5689568 | 0.88 | NR1H4 (0.42) | NR1H4ALDH1A1KDM4E | |
| SCHEMBL4666128 | 0.87 | NR1H4 (0.52) | NR1H4KMT2AATM | |
| SCHEMBL5709135 | 0.87 | NR1H4 (0.52) | NR1H4KMT2AATM | |
| SCHEMBL3836167 | 0.87 | NR1H4 (0.45) | NR1H4ALDH1A1KDM4E | |
| SCHEMBL4598864 | 0.87 | NR1H4 (0.47) | NR1H4ALDH1A1KDM4EKMT2AATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1345918-A1 | CHEMICAL COMPOUNDS | AstraZeneca AB (SE) | 2003-09-24 | — | — | EP | claimed |
| WO-2002050051-A1 | CHEMICAL COMPOUNDS | ASTRAZENECA AB (SE) | 2002-06-27 | — | — | WO | claimed |
| EP-1699759-A1 | DIPHENYLAZETIDINONE DERIVATES POSSESSING CHOLESTEROL ABSORPTION INHIBITORY ACTIVITY | AstraZeneca AB (SE) | 2006-09-13 | — | — | EP | disclosed |
| EP-1675820-A2 | PROPIONIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF LIPID DISORDERS | AstraZeneca AB (SE) | 2006-07-05 | — | — | EP | disclosed |
| WO-2005061452-A1 | DIPHENYLAZETIDINONE DERIVATES POSSESSING CHOLESTEROL ABSORPTION INHIBITORY ACTIVITY | ASTRAZENECA AB (SE) | 2005-07-07 | — | — | WO | disclosed |
| WO-2004113270-A2 | PROPIONIC ACID DERIVATIVES USEFUL IN THE TREATMENT OF LIPID DISORDERS | ASTRAZENECA AB (SE) | 2004-12-29 | — | — | WO | disclosed |
| EP-1458677-A1 | 3-PHENYL-2-ARYLALKYLTHIOPROPIONIC ACID DERIVATIVES AS SELECTIVE AGONISTS OF PPAR-ALPHA | Astrazeneca AB (SE) | 2004-09-22 | — | — | EP | disclosed |
| WO-2003051826-A1 | 3-PHENYL-2-ARYLALKYLTHIOPROPIONIC ACID DERIVATIVES AS SELECTIVE AGONISTS OF PPAR-ALPHA | ASTRAZENECA AB (SE) | 2003-06-26 | — | — | WO | disclosed |