Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 20/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4491158 | 0.89 | REN (0.42) | RENKCNH2CYP3A4 | |
| SCHEMBL4491163 | 0.89 | REN (0.42) | RENKCNH2CYP3A4 | |
| SCHEMBL4514582 | 0.84 | REN (0.41) | RENKCNH2CYP3A4 | |
| SCHEMBL4498916 | 0.84 | REN (0.41) | RENKCNH2CYP3A4 | |
| SCHEMBL17005404 | 0.78 | REN (0.50) | RENKCNH2CYP3A4 | |
| SCHEMBL90351 | 0.74 | REN (0.46) | RENKCNH2CYP3A4 | |
| SCHEMBL89696 | 0.74 | REN (0.46) | RENKCNH2CYP3A4 | |
| SCHEMBL1913362 | 0.74 | REN (0.50) | RENKCNH2CYP3A4 | |
| SCHEMBL4496291 | 0.74 | REN (0.50) | RENKCNH2CYP3A4 | |
| SCHEMBL89818 | 0.73 | REN (0.41) | RENKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1907359-A2 | 3,5-SUBSTITUTED PIPERIDINE DERIVATIVES EFFECTIVE ON RENIN-RELATED DISORDERS | Novartis AG (CH) | 2008-04-09 | — | — | EP | disclosed |
| WO-2007006534-A2 | PIPERIDINE DERIVATIVES USEFUL IN THE DIAGNOSTIC AND THERAPEUTIC TREATMENT OF DISEASES DEPENDING ON RENIN ACTIVITY | NOVARTIS AG (CH) | 2007-01-18 | — | — | WO | disclosed |