Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QPCT | Q16769 | 7/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.46 |
| ▸ | PRKCG | P05129 | 1/20 | 0.46 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | ROS1 | P08922 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | AKT2 | P31751 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4908299 | 0.93 | ROCK2 (0.48) | QPCTROCK2PLK4CHEK1DAPK3 | |
| SCHEMBL4598622 | 0.86 | QPCT (0.50) | QPCTROCK2PLK4CHEK1DAPK3 | |
| SCHEMBL4599132 | 0.85 | QPCT (0.47) | QPCTROCK2PLK4CHEK1DAPK3 | |
| SCHEMBL4907508 | 0.82 | QPCT (0.46) | QPCTROCK2PLK4CHEK1DAPK3 | |
| SCHEMBL4596911 | 0.81 | NAMPT (0.47) | QPCTROCK2PLK4CHEK1DAPK3 | |
| SCHEMBL4598322 | 0.81 | ROCK2 (0.44) | QPCTROCK2PLK4CHEK1DAPK3 | |
| SCHEMBL4905319 | 0.81 | QPCT (0.46) | QPCTROCK2PLK4CHEK1DAPK3 | |
| SCHEMBL4597195 | 0.80 | ROCK2 (0.44) | QPCTROCK2PLK4CHEK1DAPK3 | |
| SCHEMBL4599119 | 0.80 | ROCK2 (0.41) | QPCTROCK2PLK4CHEK1DAPK3 | |
| SCHEMBL4906532 | 0.78 | ROCK2 (0.45) | QPCTROCK2PLK4CHEK1DAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910312-A1 | QUADRATIC ACID II DERIVATIVES | Merck Patent GmbH (DE) | 2008-04-16 | — | — | EP | claimed |
| WO-2007014608-A1 | QUADRATIC ACID II DERIVATIVES | MERCK PATENT GMBH (DE) | 2007-02-08 | — | — | WO | claimed |