Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 6/20 | 0.55 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.55 |
| ▸ | NR1H3 | Q13133 | 6/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 8/20 | 0.42 |
| ▸ | AKR1C2 | P52895 | 8/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.37 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3473684 | 0.83 | RXRA (0.56) | RXRANR1H2NR1H3NR3C2PTGS2 | |
| SCHEMBL3473241 | 0.79 | RXRA (0.54) | RXRANR1H2NR1H3NR3C2PTGS2 | |
| SCHEMBL3473165 | 0.76 | RXRA (0.57) | RXRANR1H2NR1H3 | |
| SCHEMBL3473121 | 0.76 | RXRA (0.68) | RXRANR1H2NR1H3NR3C2PTGS2 | |
| SCHEMBL3473215 | 0.75 | RXRA (0.69) | RXRANR1H2NR1H3NR3C2PTGS2 | |
| SCHEMBL3472699 | 0.75 | RXRA (0.66) | RXRANR1H2NR1H3NR3C2PTGS2 | |
| SCHEMBL3473042 | 0.74 | RXRA (0.56) | RXRANR1H2NR1H3NR3C2PTGS2 | |
| SCHEMBL3471639 | 0.74 | RXRA (0.64) | RXRANR1H2NR1H3NR3C2PTGS2 | |
| SCHEMBL3471064 | 0.74 | RXRA (0.68) | RXRANR1H2NR1H3NR3C2PTGS2 | |
| SCHEMBL3471768 | 0.73 | RXRA (0.65) | RXRANR1H2NR1H3NR3C2PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910307-A1 | PYRAZOLE BASED LXR MODULATORS | Exelixis, Inc. (US) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007002559-A1 | PYRAZOLE BASED LXR MODULATORS | EXELIXIS, INC. (US) | 2007-01-04 | — | — | WO | disclosed |