SCHEMBL4599078

SCHEMBL4599078

CC(COc1ccc(Cl)cc1)C(N)=O

nearest known ligand 0.58

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.58
PPARG P37231 1/20 0.49
PPARA Q07869 1/20 0.49
MEN1 O00255 1/20 0.47
ALDH1A1 P00352 1/20 0.47
RAB9A P51151 1/20 0.47
KMT2A Q03164 1/20 0.47
SCN4A P35499 2/20 0.46
SMN1; SMN2 Q16637 1/20 0.44
MAOA P21397 1/20 0.44
MAOB P27338 1/20 0.44
MAPK1 P28482 1/20 0.43
SIGMAR1 Q99720 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28619870 0.84 PPARA (0.58) CYP1A2PPARGPPARAMEN1ALDH1A1
SCHEMBL21895800 0.84 PPARA (0.58) CYP1A2PPARGPPARAMEN1ALDH1A1
SCHEMBL1305299 0.84 PPARA (0.58) CYP1A2PPARGPPARAMEN1ALDH1A1
SCHEMBL7447565 0.84 CYP1A2 (0.51) CYP1A2PPARGPPARAMEN1ALDH1A1
SCHEMBL11643677 0.83 CYP1A2 (0.54) CYP1A2PPARGPPARAMEN1ALDH1A1
Water SCHEMBL11798405 0.83 PPARA (0.56) CYP1A2PPARGPPARAMEN1ALDH1A1
SCHEMBL10612565 0.82 LMNA (0.58) PPARGPPARASCN4AMAOA
SCHEMBL6809829 0.82 LMNA (0.58) PPARGPPARASCN4AMAOA
SCHEMBL11799711 0.81 PPARA (0.51) CYP1A2PPARGPPARAMEN1ALDH1A1
SCHEMBL11504001 0.81 CYP1A2 (0.53) CYP1A2PPARGPPARAMEN1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1910309-A2 CYCLOALKYL AMINO-HYDANTOIN COMPOUNDS AND USE THEREOF FOR ß-SECRETASE MODULATION Wyeth (US) 2008-04-16 EP claimed
WO-2007016012-A2 CYCLOALKYL AMINO-HYDANTOIN COMPOUNDS AND USE THEREOF FOR β-SECRETASE MODULATION WYETH (US) 2007-02-08 WO claimed
EP-1910309-A2 CYCLOALKYL AMINO-HYDANTOIN COMPOUNDS AND USE THEREOF FOR ß-SECRETASE MODULATION Wyeth (US) 2008-04-16 EP disclosed
WO-2007016012-A2 CYCLOALKYL AMINO-HYDANTOIN COMPOUNDS AND USE THEREOF FOR β-SECRETASE MODULATION WYETH (US) 2007-02-08 WO disclosed