Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.42 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.42 |
| ▸ | PRKACA | P17612 | 4/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 4/20 | 0.42 |
| ▸ | AKT1 | P31749 | 4/20 | 0.42 |
| ▸ | GSK3B | P49841 | 4/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 4/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.42 |
| ▸ | PRKG1 | Q13976 | 4/20 | 0.42 |
| ▸ | PKN2 | Q16513 | 4/20 | 0.42 |
| ▸ | CDC42BPA | Q5VT25 | 4/20 | 0.42 |
| ▸ | HIPK4 | Q8NE63 | 4/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.42 |
| ▸ | AKT2 | P31751 | 3/20 | 0.42 |
| ▸ | CLK2 | P49760 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4925124 | 0.90 | MAPKAPK2 (0.53) | HIF1AMAPKAPK2EGFRPPARGROCK2 | |
| SCHEMBL4917135 | 0.88 | CHEK2 (0.46) | HIF1AMAPKAPK2EGFRROCK2CHEK2 | |
| SCHEMBL4920649 | 0.88 | MAPKAPK2 (0.44) | HIF1AMAPKAPK2EGFRPPARGROCK2 | |
| SCHEMBL4596918 | 0.84 | GSK3B (0.46) | HIF1AMAPKAPK2EGFRPPARGROCK2 | |
| SCHEMBL4598269 | 0.84 | KDM1A (0.46) | HIF1AMAPKAPK2EGFRPPARGROCK2 | |
| SCHEMBL4916045 | 0.82 | EGFR (0.57) | HIF1AMAPKAPK2EGFRPPARGROCK2 | |
| SCHEMBL4919796 | 0.82 | GSK3B (0.48) | HIF1AMAPKAPK2EGFRROCK2CHEK2 | |
| SCHEMBL4917069 | 0.82 | EGFR (0.50) | HIF1AMAPKAPK2EGFRROCK2CHEK2 | |
| SCHEMBL4920693 | 0.81 | RPS6KB1 (0.41) | HIF1AMAPKAPK2EGFRPPARGROCK2 | |
| SCHEMBL4906887 | 0.81 | MAPKAPK2 (0.54) | HIF1AMAPKAPK2EGFRROCK2CHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080312244-A1 | Squaric Acid Derivatives as Protein Kinase Inhibitors | MERCK PATENT GMBH (DE) | 2008-12-18 | — | — | US | claimed |
| EP-1910277-A1 | QUADRATIC ACID DERIVATIVES IN THE FORM OF A PROTEIN KINASE INHIBITORS | Merck Patent GmbH (DE) | 2008-04-16 | — | — | EP | claimed |
| WO-2007014607-A1 | QUADRATIC ACID DERIVATIVES IN THE FORM OF A PROTEIN KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2007-02-08 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312244-A1 | Squaric Acid Derivatives as Protein Kinase Inhibitors | CHEK1, CHEK2, SIK1 | HIF1A 1888/4885MAPKAPK2 377/4885EGFR 1602/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.